Variant report

Variant	rs56071381
Chromosome Location	chr10:45907136-45907137
allele	G/T
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Distal block	Cell Line	Cell type
1	chr10:45906072..45907665-chr10:45916489..45918577,2	K562	blood:
2	chr10:45891814..45893692-chr10:45907011..45909582,2	K562	blood:
3	chr10:45906079..45908146-chr10:45910632..45912489,2	K562	blood:
4	chr10:45898269..45903798-chr10:45904032..45907291,6	K562	blood:

Extended variants
information (count: 37 )
Associated
traits (count: 1 )

rSNPs within LD-proxies of this variant (count:31)

rs_ID	r²[population]
rs10900215	0.85[AMR][1000 genomes];0.98[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs10900228	1.00[ASN][1000 genomes]
rs11239501	0.89[EUR][1000 genomes]
rs11239506	0.92[EUR][1000 genomes]
rs11239512	0.92[EUR][1000 genomes]
rs11239515	0.98[EUR][1000 genomes]
rs11239516	0.83[AMR][1000 genomes];0.98[EUR][1000 genomes]
rs11239517	0.83[AMR][1000 genomes];0.98[EUR][1000 genomes]
rs11239519	0.80[AMR][1000 genomes];0.99[EUR][1000 genomes]
rs11239520	0.90[AMR][1000 genomes];0.98[EUR][1000 genomes]
rs11239523	0.90[AMR][1000 genomes];0.91[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs11239524	0.80[AFR][1000 genomes];0.97[AMR][1000 genomes];0.83[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs11239534	1.00[ASN][1000 genomes]
rs11239540	1.00[ASN][1000 genomes]
rs11239572	1.00[ASN][1000 genomes]
rs12355888	1.00[ASN][1000 genomes]
rs17444064	0.92[EUR][1000 genomes]
rs28395868	1.00[ASN][1000 genomes]
rs28586924	1.00[ASN][1000 genomes]
rs41526545	0.92[EUR][1000 genomes]
rs55789336	0.91[EUR][1000 genomes]
rs55837212	0.87[EUR][1000 genomes]
rs55866086	0.95[EUR][1000 genomes]
rs61854113	1.00[ASN][1000 genomes]
rs61854124	1.00[ASN][1000 genomes]
rs6593484	0.92[EUR][1000 genomes]
rs72796464	0.98[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs72796496	1.00[ASN][1000 genomes]
rs72798218	1.00[ASN][1000 genomes]
rs72798220	1.00[ASN][1000 genomes]
rs7907779	0.92[EUR][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:6 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv895105	chr10:45636867-45928822	Enhancers Weak transcription Bivalent Enhancer Bivalent/Poised TSS Flanking Bivalent TSS/Enh Flanking Active TSS Active TSS Strong transcription Transcr. at gene 5' and 3' Genic enhancers ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA	13 gene(s)	inside rSNPs	diseases
2	nsv430166	chr10:45668894-46148794	Bivalent Enhancer Strong transcription Weak transcription Enhancers Flanking Bivalent TSS/Enh Bivalent/Poised TSS Flanking Active TSS Active TSS Genic enhancers ZNF genes & repeats Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	15 gene(s)	inside rSNPs	diseases
3	nsv993428	chr10:45742877-46224333	Enhancers Active TSS Weak transcription ZNF genes & repeats Bivalent/Poised TSS Strong transcription Flanking Active TSS Bivalent Enhancer Flanking Bivalent TSS/Enh Genic enhancers Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	19 gene(s)	inside rSNPs	diseases
4	nsv895107	chr10:45850300-45953767	Strong transcription Enhancers Bivalent/Poised TSS Bivalent Enhancer Flanking Active TSS Active TSS ZNF genes & repeats Genic enhancers Weak transcription Flanking Bivalent TSS/Enh Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	2 gene(s)	inside rSNPs	diseases
5	nsv895108	chr10:45878908-46224333	Active TSS Weak transcription Enhancers ZNF genes & repeats Strong transcription Bivalent Enhancer Flanking Active TSS Genic enhancers Flanking Bivalent TSS/Enh Bivalent/Poised TSS Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	16 gene(s)	inside rSNPs	diseases
6	nsv895109	chr10:45882741-46210665	Weak transcription Strong transcription Enhancers Active TSS Genic enhancers Flanking Active TSS ZNF genes & repeats Flanking Bivalent TSS/Enh Bivalent Enhancer Bivalent/Poised TSS Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	12 gene(s)	inside rSNPs	diseases

mRNA abundance (count:1)

SNP	Gene	Cis/trans	Tissue	Source
rs56071381	ALOX5	Cis_1M	lymphoblastoid	RTeQTL

Chromatin state (count:25 , 50 per page) page: 1

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr10:45884000-45907400	Weak transcription	Spleen	Spleen
2	chr10:45891600-45914200	Weak transcription	Thymus	Thymus
3	chr10:45894400-45912800	Weak transcription	Placenta	Placenta
4	chr10:45899400-45914000	Weak transcription	Rectal Mucosa Donor 29	rectum
5	chr10:45900000-45913000	Weak transcription	Primary Natural Killer cells fromperipheralblood	blood
6	chr10:45900200-45908600	Strong transcription	Primary B cells from peripheral blood	blood
7	chr10:45901200-45908400	Strong transcription	Primary B cells from cord blood	blood
8	chr10:45901600-45913200	Weak transcription	Primary hematopoietic stem cells	blood
9	chr10:45904600-45908600	Strong transcription	Monocytes-CD14+_RO01746	blood
10	chr10:45905400-45913400	Weak transcription	iPS DF 19.11 Cell Line	embryonic stem cell
11	chr10:45905400-45913400	Weak transcription	Lung	lung
12	chr10:45905400-45914000	Weak transcription	Gastric	stomach
13	chr10:45905800-45914200	Weak transcription	Pancreatic Islets	Pancreatic Islet
14	chr10:45906200-45913600	Weak transcription	Brain Hippocampus Middle	brain
15	chr10:45906400-45907400	Enhancers	H9 Derived Neuronal Progenitor Cultured Cells	ES cell derived
16	chr10:45906400-45909800	Strong transcription	Primary monocytes fromperipheralblood	blood
17	chr10:45906600-45907400	Enhancers	H9 Derived Neuron Cultured Cells	ES cell derived
18	chr10:45906600-45913400	Weak transcription	Primary hematopoietic stem cells G-CSF-mobilized Male	--
19	chr10:45907000-45907200	Bivalent Enhancer	H1 Derived Mesenchymal Stem Cells	ES cell derived
20	chr10:45907000-45907200	Enhancers	Primary T helper memory cells from peripheral blood 2	blood
21	chr10:45907000-45907400	Enhancers	K562	blood
22	chr10:45907000-45908400	Strong transcription	Fetal Intestine Small	intestine
23	chr10:45907000-45908600	Strong transcription	Primary mononuclear cells fromperipheralblood	Blood
24	chr10:45907000-45909000	Strong transcription	Primary neutrophils fromperipheralblood	blood
25	chr10:45907000-45914000	Weak transcription	Fetal Intestine Large	intestine

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