Variant report

Variant	rs2377523
Chromosome Location	chr10:49843196-49843197
allele	A/G
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Distal block	Cell Line	Cell type	Cell Stage
1	chr10:49837862..49840407-chr10:49842684..49844891,2	K562	blood:

Extended variants
information (count: 24 )
Associated
traits (count: 2 )

rSNPs within LD-proxies of this variant (count:22)

rs_ID	r²[population]
rs10776629	0.81[AMR][1000 genomes];0.88[EUR][1000 genomes]
rs10776630	0.81[AFR][1000 genomes];0.98[AMR][1000 genomes];0.96[EUR][1000 genomes];0.85[ASN][1000 genomes]
rs10776631	0.83[AFR][1000 genomes];0.98[AMR][1000 genomes];0.96[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs10776632	0.96[CEU][hapmap];1.00[CHB][hapmap];1.00[JPT][hapmap];0.86[AMR][1000 genomes];0.96[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs10857612	0.84[AFR][1000 genomes];0.98[AMR][1000 genomes];0.96[EUR][1000 genomes];0.85[ASN][1000 genomes]
rs10857613	0.96[CEU][hapmap];0.90[CHB][hapmap];1.00[JPT][hapmap];0.90[AMR][1000 genomes];0.95[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs10857614	0.91[CEU][hapmap];0.90[CHB][hapmap];0.90[JPT][hapmap];0.86[EUR][1000 genomes];0.83[ASN][1000 genomes]
rs1822861	0.96[CEU][hapmap];0.95[CHB][hapmap];1.00[JPT][hapmap];0.86[AMR][1000 genomes];0.96[EUR][1000 genomes];0.91[ASN][1000 genomes]
rs2377522	1.00[CEU][hapmap];0.91[CHB][hapmap];1.00[JPT][hapmap];0.89[YRI][hapmap];0.98[AFR][1000 genomes];0.99[AMR][1000 genomes];0.99[EUR][1000 genomes];0.93[ASN][1000 genomes]
rs2377595	0.81[CHB][hapmap];0.82[AFR][1000 genomes];0.88[AMR][1000 genomes];0.82[EUR][1000 genomes]
rs2377596	0.81[EUR][1000 genomes]
rs34939981	0.95[EUR][1000 genomes];0.85[ASN][1000 genomes]
rs3844493	0.96[CEU][hapmap];0.95[CHB][hapmap];1.00[JPT][hapmap];0.89[YRI][hapmap];0.87[AFR][1000 genomes];0.97[AMR][1000 genomes];0.96[EUR][1000 genomes];0.92[ASN][1000 genomes]
rs3845284	0.83[EUR][1000 genomes]
rs3853123	0.81[AMR][1000 genomes];0.88[EUR][1000 genomes]
rs3910909	0.86[AMR][1000 genomes];0.99[EUR][1000 genomes];0.91[ASN][1000 genomes]
rs3910910	1.00[CEU][hapmap];0.91[CHB][hapmap];1.00[JPT][hapmap];0.86[AMR][1000 genomes];0.99[EUR][1000 genomes];0.91[ASN][1000 genomes]
rs3910911	1.00[CEU][hapmap];0.91[CHB][hapmap];1.00[JPT][hapmap];0.89[YRI][hapmap];0.98[AFR][1000 genomes];0.99[AMR][1000 genomes];0.99[EUR][1000 genomes];0.93[ASN][1000 genomes]
rs3910912	0.81[JPT][hapmap]
rs4838428	0.91[AMR][1000 genomes];0.96[EUR][1000 genomes];0.96[ASN][1000 genomes]
rs4838429	1.00[CEU][hapmap];1.00[CHB][hapmap];1.00[JPT][hapmap];0.89[YRI][hapmap];0.99[AFR][1000 genomes];1.00[AMR][1000 genomes];0.99[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs7904633	0.86[AFR][1000 genomes];0.98[AMR][1000 genomes];0.96[EUR][1000 genomes];0.86[ASN][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:2 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv895371	chr10:49492075-50232180	Weak transcription Active TSS Bivalent Enhancer Flanking Active TSS Enhancers Flanking Bivalent TSS/Enh Strong transcription Bivalent/Poised TSS Transcr. at gene 5' and 3' Genic enhancers ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA	35 gene(s)	inside rSNPs	diseases
2	nsv895372	chr10:49576878-49933488	Enhancers Weak transcription Bivalent Enhancer Genic enhancers Strong transcription Flanking Bivalent TSS/Enh Flanking Active TSS Transcr. at gene 5' and 3' ZNF genes & repeats Active TSS Bivalent/Poised TSS	TF binding region CpG island Chromatin interactive region lncRNA	20 gene(s)	inside rSNPs	diseases

mRNA abundance (count:2)

SNP	Gene	Cis/trans	Tissue	Source
rs2377523	ARHGAP22	cis	Artery Aorta	GTEx
rs2377523	ARHGAP22	cis	Artery Tibial	GTEx

Chromatin state (count:57 , 50 per page) page: 1 2

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr10:49813400-49844200	Weak transcription	Pancreas	Pancrea
2	chr10:49831600-49843400	Weak transcription	Right Atrium	heart
3	chr10:49840200-49848600	Enhancers	Primary monocytes fromperipheralblood	blood
4	chr10:49840400-49845000	Enhancers	Primary hematopoietic stem cells short term culture	blood
5	chr10:49840800-49844000	Enhancers	Primary hematopoietic stem cells	blood
6	chr10:49840800-49844400	Enhancers	NHDF-Ad	bronchial
7	chr10:49841000-49843200	Enhancers	Rectal Mucosa Donor 31	rectum
8	chr10:49841000-49843400	Enhancers	Primary B cells from peripheral blood	blood
9	chr10:49841000-49843800	Enhancers	Foreskin Fibroblast Primary Cells skin01	Skin
10	chr10:49841000-49844000	Enhancers	Dnd41	blood
11	chr10:49841000-49845200	Enhancers	Primary hematopoietic stem cells G-CSF-mobilized Female	--
12	chr10:49841200-49843200	Enhancers	Rectal Mucosa Donor 29	rectum
13	chr10:49841400-49843400	Enhancers	Aorta	Aorta
14	chr10:49841600-49843400	Enhancers	Foreskin Fibroblast Primary Cells skin02	Skin
15	chr10:49841600-49843400	Flanking Active TSS	Monocytes-CD14+_RO01746	blood
16	chr10:49841600-49843800	Bivalent Enhancer	Primary T cells fromperipheralblood	blood
17	chr10:49841600-49843800	Enhancers	Primary Natural Killer cells fromperipheralblood	blood
18	chr10:49841600-49844600	Enhancers	Fetal Thymus	thymus
19	chr10:49841800-49843200	Enhancers	Primary T cells from cord blood	blood
20	chr10:49841800-49843200	Enhancers	Primary T regulatory cells fromperipheralblood	blood
21	chr10:49841800-49843400	Enhancers	Right Ventricle	heart
22	chr10:49841800-49843400	Enhancers	Spleen	Spleen
23	chr10:49842000-49843200	Enhancers	NH-A	brain
24	chr10:49842000-49843200	Flanking Active TSS	Osteobl	bone
25	chr10:49842000-49843400	Enhancers	Brain Angular Gyrus	brain
26	chr10:49842000-49843400	Enhancers	NHLF	lung
27	chr10:49842000-49844400	Enhancers	Brain Substantia Nigra	brain
28	chr10:49842000-49844800	Enhancers	Adipose Nuclei	Adipose
29	chr10:49842000-49859400	Weak transcription	Brain Dorsolateral Prefrontal Cortex	brain
30	chr10:49842200-49843200	Weak transcription	Skeletal Muscle Female	skeletal muscle
31	chr10:49842200-49843400	Enhancers	IMR90 fetal lung fibroblasts Cell Line	lung
32	chr10:49842400-49843200	Enhancers	Left Ventricle	heart
33	chr10:49842400-49843400	Enhancers	Brain Cingulate Gyrus	brain
34	chr10:49842400-49843400	Weak transcription	Fetal Muscle Leg	muscle
35	chr10:49842400-49843600	Bivalent Enhancer	Placenta	Placenta
36	chr10:49842400-49844800	Enhancers	Brain Hippocampus Middle	brain
37	chr10:49842600-49843200	Flanking Active TSS	Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	ES cell derived
38	chr10:49842600-49843200	Flanking Active TSS	Adipose Derived Mesenchymal Stem Cell Cultured Cells	ES cell derived
39	chr10:49842600-49843200	Bivalent Enhancer	Stomach Smooth Muscle	stomach
40	chr10:49842600-49843400	Flanking Active TSS	Bone Marrow Derived Cultured Mesenchymal Stem Cells	Bone marrow
41	chr10:49842600-49843400	Enhancers	Primary T killer memory cells from peripheral blood	blood
42	chr10:49842600-49843400	Flanking Active TSS	HSMM	muscle
43	chr10:49842600-49844200	Weak transcription	H1 Derived Mesenchymal Stem Cells	ES cell derived
44	chr10:49842600-49844600	Enhancers	Primary T helper 17 cells PMA-I stimulated	--
45	chr10:49842800-49843200	Enhancers	Primary T helper memory cells from peripheral blood 2	blood
46	chr10:49842800-49843200	Flanking Active TSS	Muscle Satellite Cultured Cells	--
47	chr10:49842800-49843200	Flanking Active TSS	HSMMtube	muscle
48	chr10:49842800-49844400	Weak transcription	Brain Inferior Temporal Lobe	brain
49	chr10:49842800-49848000	Weak transcription	iPS DF 19.11 Cell Line	embryonic stem cell
50	chr10:49843000-49843200	Enhancers	Duodenum Mucosa	Duodenum

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