Variant report

Variant	rs3910909
Chromosome Location	chr10:49844458-49844459
allele	A/G
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Distal block	Cell Line	Cell type	Cell Stage
1	chr10:49837862..49840407-chr10:49842684..49844891,2	K562	blood:

Extended variants
information (count: 23 )
Associated
traits (count: 3 )

rSNPs within LD-proxies of this variant (count:21)

rs_ID	r²[population]
rs10776629	0.88[EUR][1000 genomes];0.80[ASN][1000 genomes]
rs10776630	0.86[AMR][1000 genomes];0.96[EUR][1000 genomes];0.91[ASN][1000 genomes]
rs10776631	0.86[AMR][1000 genomes];0.96[EUR][1000 genomes];0.87[ASN][1000 genomes]
rs10776632	0.86[AFR][1000 genomes];1.00[AMR][1000 genomes];0.97[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs10857612	0.86[AMR][1000 genomes];0.96[EUR][1000 genomes];0.91[ASN][1000 genomes]
rs10857613	0.93[AMR][1000 genomes];0.96[EUR][1000 genomes];0.87[ASN][1000 genomes]
rs10857614	0.87[EUR][1000 genomes]
rs1822861	0.97[AFR][1000 genomes];1.00[AMR][1000 genomes];0.97[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs2377522	0.87[AMR][1000 genomes];0.99[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs2377523	0.86[AMR][1000 genomes];0.99[EUR][1000 genomes];0.91[ASN][1000 genomes]
rs2377595	0.82[EUR][1000 genomes]
rs2377596	0.86[AMR][1000 genomes];0.82[EUR][1000 genomes]
rs34939981	0.95[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs3844493	0.85[AMR][1000 genomes];0.96[EUR][1000 genomes];0.85[ASN][1000 genomes]
rs3845284	0.83[EUR][1000 genomes]
rs3853123	0.88[EUR][1000 genomes];0.80[ASN][1000 genomes]
rs3910910	1.00[AFR][1000 genomes];1.00[AMR][1000 genomes];1.00[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs3910911	0.87[AMR][1000 genomes];0.99[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs4838428	0.95[AMR][1000 genomes];0.97[EUR][1000 genomes];0.88[ASN][1000 genomes]
rs4838429	0.86[AMR][1000 genomes];0.99[EUR][1000 genomes];0.91[ASN][1000 genomes]
rs7904633	0.86[AMR][1000 genomes];0.96[EUR][1000 genomes];0.92[ASN][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:2 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv895371	chr10:49492075-50232180	Weak transcription Active TSS Bivalent Enhancer Flanking Active TSS Enhancers Flanking Bivalent TSS/Enh Strong transcription Bivalent/Poised TSS Transcr. at gene 5' and 3' Genic enhancers ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA	35 gene(s)	inside rSNPs	diseases
2	nsv895372	chr10:49576878-49933488	Enhancers Weak transcription Bivalent Enhancer Genic enhancers Strong transcription Flanking Bivalent TSS/Enh Flanking Active TSS Transcr. at gene 5' and 3' ZNF genes & repeats Active TSS Bivalent/Poised TSS	TF binding region CpG island Chromatin interactive region lncRNA	20 gene(s)	inside rSNPs	diseases

mRNA abundance (count:3)

SNP	Gene	Cis/trans	Tissue	Source
rs3910909	ARHGAP22	cis	Whole Blood	GTEx
rs3910909	ARHGAP22	cis	Artery Aorta	GTEx
rs3910909	ARHGAP22	cis	Artery Tibial	GTEx

Chromatin state (count:36 , 50 per page) page: 1

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr10:49840200-49848600	Enhancers	Primary monocytes fromperipheralblood	blood
2	chr10:49840400-49845000	Enhancers	Primary hematopoietic stem cells short term culture	blood
3	chr10:49841000-49845200	Enhancers	Primary hematopoietic stem cells G-CSF-mobilized Female	--
4	chr10:49841600-49844600	Enhancers	Fetal Thymus	thymus
5	chr10:49842000-49844800	Enhancers	Adipose Nuclei	Adipose
6	chr10:49842000-49859400	Weak transcription	Brain Dorsolateral Prefrontal Cortex	brain
7	chr10:49842400-49844800	Enhancers	Brain Hippocampus Middle	brain
8	chr10:49842600-49844600	Enhancers	Primary T helper 17 cells PMA-I stimulated	--
9	chr10:49842800-49848000	Weak transcription	iPS DF 19.11 Cell Line	embryonic stem cell
10	chr10:49843000-49844600	Enhancers	Mesenchymal Stem Cell Derived Chondrocyte Cultured Cells	embryonic stem cell
11	chr10:49843000-49844600	Enhancers	GM12878-XiMat	blood
12	chr10:49843200-49844600	Enhancers	Adipose Derived Mesenchymal Stem Cell Cultured Cells	ES cell derived
13	chr10:49843200-49844600	Enhancers	Skeletal Muscle Female	skeletal muscle
14	chr10:49843400-49844600	Enhancers	Bone Marrow Derived Cultured Mesenchymal Stem Cells	Bone marrow
15	chr10:49843400-49845000	Bivalent Enhancer	Primary B cells from peripheral blood	blood
16	chr10:49843400-49845200	Enhancers	Primary hematopoietic stem cells G-CSF-mobilized Male	--
17	chr10:49843400-49845200	Genic enhancers	Foreskin Fibroblast Primary Cells skin02	Skin
18	chr10:49843400-49846600	Enhancers	Monocytes-CD14+_RO01746	blood
19	chr10:49843400-49847400	Weak transcription	Brain Angular Gyrus	brain
20	chr10:49843400-49862600	Weak transcription	NHLF	lung
21	chr10:49843600-49845200	Enhancers	Placenta	Placenta
22	chr10:49843800-49844800	Weak transcription	Primary Natural Killer cells fromperipheralblood	blood
23	chr10:49843800-49845000	Genic enhancers	Foreskin Fibroblast Primary Cells skin01	Skin
24	chr10:49843800-49847400	Weak transcription	HSMM	muscle
25	chr10:49843800-49847400	Weak transcription	HSMMtube	muscle
26	chr10:49844000-49847000	Weak transcription	Primary hematopoietic stem cells	blood
27	chr10:49844000-49847400	Weak transcription	Muscle Satellite Cultured Cells	--
28	chr10:49844000-49863400	Weak transcription	Breast variant Human Mammary Epithelial Cells (vHMEC)	Breast
29	chr10:49844200-49844600	Enhancers	H1 Derived Mesenchymal Stem Cells	ES cell derived
30	chr10:49844200-49845000	Enhancers	Spleen	Spleen
31	chr10:49844200-49845200	Enhancers	Pancreas	Pancrea
32	chr10:49844200-49847400	Weak transcription	Osteobl	bone
33	chr10:49844400-49844600	Enhancers	Brain Inferior Temporal Lobe	brain
34	chr10:49844400-49844600	Bivalent Enhancer	Fetal Muscle Trunk	muscle
35	chr10:49844400-49847000	Weak transcription	NHDF-Ad	bronchial
36	chr10:49844400-49847200	Weak transcription	Brain Substantia Nigra	brain

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