Variant report

Variant	rs28395865
Chromosome Location	chr10:45877899-45877900
allele	C/T
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Distal block	Cell Line	Cell type	Cell Stage
1	chr10:45869704..45872011-chr10:45875506..45878430,2	K562	blood:
2	chr10:45873911..45876149-chr10:45876487..45879214,3	K562	blood:

Extended variants
information (count: 106 )
Associated
traits (count: 1 )

rSNPs within LD-proxies of this variant (count:102)

rs_ID	r²[population]
rs10900212	0.90[AMR][1000 genomes];0.97[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs11239486	0.95[AMR][1000 genomes];0.95[EUR][1000 genomes];0.93[ASN][1000 genomes]
rs11239491	0.95[AMR][1000 genomes];0.96[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs11239492	0.89[AMR][1000 genomes];0.96[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs11239497	0.98[AFR][1000 genomes];1.00[AMR][1000 genomes];0.97[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs11239505	0.94[ASN][1000 genomes]
rs11511619	0.89[AMR][1000 genomes];0.94[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs11511620	0.91[AFR][1000 genomes];0.95[AMR][1000 genomes];0.95[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs11517281	0.95[AMR][1000 genomes];0.96[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs11523408	0.95[AMR][1000 genomes];0.95[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs12354712	0.88[AFR][1000 genomes];0.95[AMR][1000 genomes];0.96[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs12354742	0.95[AMR][1000 genomes];0.96[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs12354994	0.91[AMR][1000 genomes];0.87[EUR][1000 genomes];0.86[ASN][1000 genomes]
rs12356109	0.89[AMR][1000 genomes];0.96[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs12356140	0.95[AMR][1000 genomes];0.96[EUR][1000 genomes];0.88[ASN][1000 genomes]
rs12358647	0.92[ASN][1000 genomes]
rs12359299	0.95[AMR][1000 genomes];0.96[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs12359302	0.93[AMR][1000 genomes];0.94[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs12360250	0.91[AMR][1000 genomes];0.95[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs12762303	0.95[AMR][1000 genomes];0.96[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs12763738	0.95[AMR][1000 genomes];0.96[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs12764778	0.95[ASN][1000 genomes]
rs12768010	0.94[ASN][1000 genomes]
rs12774369	1.00[AMR][1000 genomes];0.97[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs12783095	1.00[AMR][1000 genomes];0.96[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs12783182	0.87[ASN][1000 genomes]
rs12783895	0.81[ASN][1000 genomes]
rs17157728	1.00[AMR][1000 genomes];0.96[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs17157733	1.00[AMR][1000 genomes];0.97[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs17157736	1.00[AMR][1000 genomes];0.97[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs1864412	0.95[AMR][1000 genomes];0.96[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs1864413	0.95[AMR][1000 genomes];0.95[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs1864414	0.93[AMR][1000 genomes];0.96[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs2082108	0.93[AMR][1000 genomes];0.96[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs2099170	0.95[AMR][1000 genomes];0.95[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs2303885	0.94[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs2310776	1.00[AMR][1000 genomes];0.97[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs34297550	0.87[ASN][1000 genomes]
rs34462692	0.83[ASN][1000 genomes]
rs34929604	0.81[ASN][1000 genomes]
rs34998367	0.87[ASN][1000 genomes]
rs35001574	0.85[ASN][1000 genomes]
rs35267934	0.87[ASN][1000 genomes]
rs35300270	0.82[ASN][1000 genomes]
rs35536930	0.82[ASN][1000 genomes]
rs35906360	0.95[AMR][1000 genomes];0.96[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs3780894	1.00[AMR][1000 genomes];0.97[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs3780896	1.00[AMR][1000 genomes];0.97[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs3780897	0.98[AMR][1000 genomes];0.97[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs3780898	0.98[AFR][1000 genomes];1.00[AMR][1000 genomes];0.97[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs3780899	1.00[AMR][1000 genomes];0.97[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs3824613	1.00[AMR][1000 genomes];0.96[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs4986832	0.95[AMR][1000 genomes];0.96[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs4987105	0.88[AFR][1000 genomes];0.95[AMR][1000 genomes];0.94[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs4987106	0.89[AMR][1000 genomes];0.93[EUR][1000 genomes];0.93[ASN][1000 genomes]
rs55717607	0.95[AMR][1000 genomes];0.96[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs55787481	0.95[AMR][1000 genomes];0.96[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs55864145	0.94[ASN][1000 genomes]
rs55965812	0.85[AFR][1000 genomes];0.95[AMR][1000 genomes];0.96[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs55978138	0.95[AMR][1000 genomes];0.96[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs55986122	0.95[AMR][1000 genomes];0.96[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs56150414	0.87[AMR][1000 genomes];0.90[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs56180358	0.95[AMR][1000 genomes];0.96[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs57063108	0.95[ASN][1000 genomes]
rs57398542	0.86[ASN][1000 genomes]
rs58238740	1.00[AMR][1000 genomes];0.97[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs58901177	0.95[ASN][1000 genomes]
rs59514896	0.82[ASN][1000 genomes]
rs60146827	0.82[ASN][1000 genomes]
rs60842538	1.00[AMR][1000 genomes];0.97[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs6413416	0.95[AMR][1000 genomes];0.96[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs6593478	0.82[ASN][1000 genomes]
rs6593482	0.93[AMR][1000 genomes];0.96[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs66489870	0.95[AMR][1000 genomes];0.96[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs67008983	0.95[AMR][1000 genomes];0.96[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs67491417	0.95[AMR][1000 genomes];0.91[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs7071714	0.87[ASN][1000 genomes]
rs7077891	1.00[AMR][1000 genomes];0.97[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs7078822	0.80[AFR][1000 genomes]
rs7080897	0.82[ASN][1000 genomes]
rs7081004	0.91[AFR][1000 genomes];0.95[AMR][1000 genomes];0.96[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs7083500	0.81[ASN][1000 genomes]
rs7084793	0.95[AMR][1000 genomes];0.96[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs7085205	0.81[ASN][1000 genomes]
rs7093687	0.91[AFR][1000 genomes];0.95[AMR][1000 genomes];0.96[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs7097429	0.82[ASN][1000 genomes]
rs71494772	0.83[ASN][1000 genomes]
rs71494775	0.95[AMR][1000 genomes];0.96[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs71494776	0.93[ASN][1000 genomes]
rs71494779	0.82[ASN][1000 genomes]
rs72561472	0.93[AMR][1000 genomes];0.86[EUR][1000 genomes];0.93[ASN][1000 genomes]
rs745986	0.94[ASN][1000 genomes]
rs7896861	0.87[ASN][1000 genomes]
rs7898465	0.87[ASN][1000 genomes]
rs7909740	0.95[AMR][1000 genomes];0.96[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs7909768	0.95[AMR][1000 genomes];0.96[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs7913488	0.95[AMR][1000 genomes];0.96[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs7917687	0.82[ASN][1000 genomes]
rs7918542	0.82[ASN][1000 genomes]
rs7919239	0.83[ASN][1000 genomes]
rs7921503	0.95[AMR][1000 genomes];0.96[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs9663661	0.95[AMR][1000 genomes];0.95[EUR][1000 genomes];0.97[ASN][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:4 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv895105	chr10:45636867-45928822	Enhancers Weak transcription Bivalent Enhancer Bivalent/Poised TSS Flanking Bivalent TSS/Enh Flanking Active TSS Active TSS Strong transcription Transcr. at gene 5' and 3' Genic enhancers ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA	13 gene(s)	inside rSNPs	diseases
2	nsv430166	chr10:45668894-46148794	Bivalent Enhancer Strong transcription Weak transcription Enhancers Flanking Bivalent TSS/Enh Bivalent/Poised TSS Flanking Active TSS Active TSS Genic enhancers ZNF genes & repeats Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	15 gene(s)	inside rSNPs	diseases
3	nsv993428	chr10:45742877-46224333	Enhancers Active TSS Weak transcription ZNF genes & repeats Bivalent/Poised TSS Strong transcription Flanking Active TSS Bivalent Enhancer Flanking Bivalent TSS/Enh Genic enhancers Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	19 gene(s)	inside rSNPs	diseases
4	nsv895107	chr10:45850300-45953767	Strong transcription Enhancers Bivalent/Poised TSS Bivalent Enhancer Flanking Active TSS Active TSS ZNF genes & repeats Genic enhancers Weak transcription Flanking Bivalent TSS/Enh Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	2 gene(s)	inside rSNPs	diseases

mRNA abundance (count:1)

SNP	Gene	Cis/trans	Tissue	Source
rs28395865	ALOX5	Cis_1M	lymphoblastoid	RTeQTL

Chromatin state (count:28 , 50 per page) page: 1

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr10:45870600-45891200	Weak transcription	Pancreatic Islets	Pancreatic Islet
2	chr10:45870800-45880400	Weak transcription	Esophagus	oesophagus
3	chr10:45871400-45904600	Weak transcription	Gastric	stomach
4	chr10:45871600-45894000	Weak transcription	Primary T cells effector/memory enriched fromperipheralblood	blood
5	chr10:45872200-45883800	Weak transcription	Primary T helper 17 cells PMA-I stimulated	--
6	chr10:45875200-45878000	Weak transcription	Fetal Intestine Small	intestine
7	chr10:45875400-45878600	Enhancers	Fetal Thymus	thymus
8	chr10:45875800-45878400	Weak transcription	iPS DF 19.11 Cell Line	embryonic stem cell
9	chr10:45875800-45891200	Weak transcription	Duodenum Mucosa	Duodenum
10	chr10:45876000-45899200	Weak transcription	Rectal Mucosa Donor 29	rectum
11	chr10:45876400-45879200	Genic enhancers	Primary neutrophils fromperipheralblood	blood
12	chr10:45876600-45878000	Enhancers	Lung	lung
13	chr10:45876600-45878800	Weak transcription	Adipose Nuclei	Adipose
14	chr10:45876600-45879000	Weak transcription	Primary hematopoietic stem cells	blood
15	chr10:45876600-45879400	Weak transcription	Primary hematopoietic stem cells G-CSF-mobilized Female	--
16	chr10:45876800-45884000	Strong transcription	Spleen	Spleen
17	chr10:45876800-45884400	Strong transcription	Primary B cells from peripheral blood	blood
18	chr10:45877000-45879000	Weak transcription	Primary hematopoietic stem cells G-CSF-mobilized Male	--
19	chr10:45877000-45880800	Genic enhancers	Primary monocytes fromperipheralblood	blood
20	chr10:45877000-45882800	Weak transcription	Brain Hippocampus Middle	brain
21	chr10:45877000-45891000	Weak transcription	Thymus	Thymus
22	chr10:45877200-45878200	Weak transcription	Placenta	Placenta
23	chr10:45877200-45878800	Genic enhancers	Monocytes-CD14+_RO01746	blood
24	chr10:45877200-45880000	Weak transcription	Primary Natural Killer cells fromperipheralblood	blood
25	chr10:45877400-45879000	Strong transcription	Primary B cells from cord blood	blood
26	chr10:45877600-45880000	Strong transcription	GM12878-XiMat	blood
27	chr10:45877800-45878800	Strong transcription	Pancreas	Pancrea
28	chr10:45877800-45884200	Strong transcription	Primary mononuclear cells fromperipheralblood	Blood

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