Variant report

Variant	rs7637665
Chromosome Location	chr3:49552295-49552296
allele	C/T
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Distal block	Cell Line	Cell type
1	chr3:49508269..49511222-chr3:49551619..49554342,2	K562	blood:
2	chr3:49551705..49554065-chr3:49554259..49559105,5	K562	blood:
3	chr3:49550928..49553417-chr3:49555152..49556759,2	MCF-7	breast:

Extended variants
information (count: 48 )
Associated
traits (count: 9 )

rSNPs within LD-proxies of this variant (count:47)

rs_ID	r²[population]
rs1050088	0.86[AMR][1000 genomes];0.93[EUR][1000 genomes]
rs10865955	0.88[EUR][1000 genomes]
rs11130192	0.81[EUR][1000 genomes]
rs11130193	0.84[EUR][1000 genomes]
rs11130194	0.81[EUR][1000 genomes]
rs11130196	0.84[EUR][1000 genomes]
rs11130199	0.86[AMR][1000 genomes];0.92[EUR][1000 genomes]
rs11130202	0.87[AMR][1000 genomes];0.96[EUR][1000 genomes]
rs11130206	0.83[AMR][1000 genomes];0.91[EUR][1000 genomes]
rs11720264	0.86[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs12488065	0.90[AMR][1000 genomes];0.95[EUR][1000 genomes]
rs12489092	0.81[AFR][1000 genomes];0.90[AMR][1000 genomes];0.96[EUR][1000 genomes]
rs13096760	0.84[EUR][1000 genomes]
rs1464566	0.81[EUR][1000 genomes]
rs1464567	0.81[EUR][1000 genomes]
rs1464568	0.81[EUR][1000 genomes]
rs1568661	0.81[AMR][1000 genomes];0.92[EUR][1000 genomes]
rs1568662	0.81[AMR][1000 genomes];0.92[EUR][1000 genomes]
rs2312461	0.93[AFR][1000 genomes];0.90[AMR][1000 genomes];0.95[EUR][1000 genomes]
rs35701831	0.84[AFR][1000 genomes];0.85[AMR][1000 genomes];0.93[EUR][1000 genomes]
rs3870337	0.80[AFR][1000 genomes];0.90[AMR][1000 genomes];0.96[EUR][1000 genomes]
rs3870338	0.80[AFR][1000 genomes];0.90[AMR][1000 genomes];0.96[EUR][1000 genomes]
rs3877784	0.84[AMR][1000 genomes];0.93[EUR][1000 genomes]
rs3924462	0.85[AMR][1000 genomes];0.93[EUR][1000 genomes]
rs3924463	0.89[EUR][1000 genomes]
rs4241406	0.80[AFR][1000 genomes];0.85[AMR][1000 genomes];0.93[EUR][1000 genomes]
rs4241408	0.80[AFR][1000 genomes];0.89[EUR][1000 genomes]
rs4459909	0.81[EUR][1000 genomes]
rs4855836	0.85[AMR][1000 genomes];0.93[EUR][1000 genomes]
rs4855839	0.83[EUR][1000 genomes]
rs4855855	0.89[AFR][1000 genomes];0.88[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs4855859	0.85[AMR][1000 genomes];0.92[EUR][1000 genomes]
rs4855861	0.85[AMR][1000 genomes];0.91[EUR][1000 genomes]
rs4855864	0.84[AMR][1000 genomes];0.92[EUR][1000 genomes]
rs4855866	0.88[EUR][1000 genomes]
rs4855873	0.81[EUR][1000 genomes]
rs4855877	0.81[EUR][1000 genomes]
rs55957735	0.81[EUR][1000 genomes]
rs59152804	0.85[EUR][1000 genomes]
rs62261185	0.83[AMR][1000 genomes];0.88[EUR][1000 genomes]
rs6784820	0.81[EUR][1000 genomes]
rs7371895	0.83[AMR][1000 genomes];0.91[EUR][1000 genomes]
rs7637999	0.84[AMR][1000 genomes];0.93[EUR][1000 genomes]
rs7643586	0.81[EUR][1000 genomes]
rs7643845	0.85[AMR][1000 genomes];0.92[EUR][1000 genomes]
rs7645445	0.81[AFR][1000 genomes];0.87[EUR][1000 genomes]
rs885592	0.90[EUR][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:1 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv834687	chr3:49448632-49631788	Flanking Active TSS Strong transcription Enhancers Weak transcription Active TSS Bivalent Enhancer Genic enhancers Transcr. at gene 5' and 3' Bivalent/Poised TSS Flanking Bivalent TSS/Enh ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	56 gene(s)	inside rSNPs	diseases

mRNA abundance (count:9)

SNP	Gene	Cis/trans	Tissue	Source
rs7637665	WDR6	cis	Adipose Subcutaneous	GTEx
rs7637665	WDR6	cis	Artery Tibial	GTEx
rs7637665	WDR6	cis	Whole Blood	GTEx
rs7637665	WDR6	cis	lung	GTEx
rs7637665	WDR6	cis	Skin Sun Exposed Lower leg	GTEx
rs7637665	RBM6	Cis_1M	lymphoblastoid	RTeQTL
rs7637665	WDR6	cis	Muscle Skeletal	GTEx
rs7637665	AMT	cis	Thyroid	GTEx
rs7637665	WDR6	cis	Nerve Tibial	GTEx

Chromatin state (count:126 , 50 per page) page: 1 2 3

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr3:49529600-49568600	Weak transcription	Primary neutrophils fromperipheralblood	blood
2	chr3:49538000-49554800	Weak transcription	iPS DF 19.11 Cell Line	embryonic stem cell
3	chr3:49538800-49553800	Weak transcription	HUVEC	blood vessel
4	chr3:49538800-49554200	Weak transcription	Aorta	Aorta
5	chr3:49539600-49568600	Weak transcription	Small Intestine	intestine
6	chr3:49542000-49553200	Weak transcription	A549	lung
7	chr3:49546200-49577000	Weak transcription	Primary T killer memory cells from peripheral blood	blood
8	chr3:49546400-49554400	Strong transcription	Foreskin Melanocyte Primary Cells skin01	Skin
9	chr3:49546600-49556200	Weak transcription	ES-WA7 Cell Line	embryonic stem cell
10	chr3:49546600-49556400	Strong transcription	H9 Derived Neuron Cultured Cells	ES cell derived
11	chr3:49547000-49572000	Weak transcription	Fetal Brain Male	brain
12	chr3:49547400-49562200	Strong transcription	Primary T cells from cord blood	blood
13	chr3:49547600-49555400	Strong transcription	iPS-18 Cell Line	embryonic stem cell
14	chr3:49547600-49556000	Strong transcription	H9 Derived Neuronal Progenitor Cultured Cells	ES cell derived
15	chr3:49547600-49556200	Strong transcription	hESC Derived CD56+ Mesoderm Cultured Cells	ES cell derived
16	chr3:49547600-49564200	Strong transcription	Fetal Intestine Small	intestine
17	chr3:49547800-49553400	Strong transcription	Primary mononuclear cells fromperipheralblood	Blood
18	chr3:49547800-49554800	Strong transcription	Fetal Muscle Leg	muscle
19	chr3:49547800-49555000	Strong transcription	Foreskin Melanocyte Primary Cells skin03	Skin
20	chr3:49547800-49555800	Strong transcription	Fetal Adrenal Gland	Adrenal Gland
21	chr3:49547800-49556200	Strong transcription	ES-UCSF4 Cell Line	embryonic stem cell
22	chr3:49547800-49556200	Strong transcription	Primary T helper cells fromperipheralblood	blood
23	chr3:49547800-49556400	Strong transcription	Primary B cells from peripheral blood	blood
24	chr3:49547800-49557200	Strong transcription	HUES64 Cell Line	embryonic stem cell
25	chr3:49547800-49557800	Strong transcription	Rectal Mucosa Donor 29	rectum
26	chr3:49547800-49558000	Strong transcription	iPS-20b Cell Line	embryonic stem cell
27	chr3:49547800-49559000	Strong transcription	Foreskin Keratinocyte Primary Cells skin03	Skin
28	chr3:49547800-49560400	Strong transcription	Fetal Thymus	thymus
29	chr3:49547800-49562800	Strong transcription	Fetal Stomach	stomach
30	chr3:49548000-49556200	Strong transcription	Primary Natural Killer cells fromperipheralblood	blood
31	chr3:49548000-49556400	Strong transcription	HUES48 Cell Line	embryonic stem cell
32	chr3:49548000-49562800	Strong transcription	Fetal Intestine Large	intestine
33	chr3:49548200-49556400	Strong transcription	Fetal Muscle Trunk	muscle
34	chr3:49548400-49554200	Weak transcription	Pancreatic Islets	Pancreatic Islet
35	chr3:49548400-49577400	Weak transcription	Primary T helper memory cells from peripheral blood 1	blood
36	chr3:49548800-49553000	Genic enhancers	Placenta	Placenta
37	chr3:49549000-49553600	Weak transcription	Fetal Heart	heart
38	chr3:49549000-49553600	Weak transcription	NHLF	lung
39	chr3:49549200-49553000	Weak transcription	iPS DF 6.9 Cell Line	embryonic stem cell
40	chr3:49549200-49553400	Weak transcription	NHEK	skin
41	chr3:49549200-49554800	Weak transcription	H1 Derived Neuronal Progenitor Cultured Cells	ES cell derived
42	chr3:49549200-49554800	Weak transcription	Fetal Lung	lung
43	chr3:49549200-49568800	Weak transcription	Osteobl	bone
44	chr3:49549400-49553000	Weak transcription	Spleen	Spleen
45	chr3:49549400-49554800	Weak transcription	Primary T killer naive cells fromperipheralblood	blood
46	chr3:49549400-49554800	Weak transcription	Mesenchymal Stem Cell Derived Chondrocyte Cultured Cells	embryonic stem cell
47	chr3:49549800-49557400	Strong transcription	Stomach Smooth Muscle	stomach
48	chr3:49550000-49554400	Strong transcription	Ganglion Eminence derived primary cultured neurospheres	brain
49	chr3:49550000-49556600	Strong transcription	Primary T helper naive cells fromperipheralblood	blood
50	chr3:49550200-49558000	Strong transcription	Duodenum Mucosa	Duodenum

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