Variant report

Variant	rs4737563
Chromosome Location	chr8:61684500-61684501
allele	C/T
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Distal block	Cell Line	Cell type
1	chr8:61565347..61567706-chr8:61683877..61685498,2	K562	blood:
2	chr8:61564005..61565776-chr8:61682362..61684915,2	MCF-7	breast:
3	chr8:61684289..61686170-chr8:61692198..61694163,2	K562	blood:
4	chr8:61678725..61681401-chr8:61683493..61686141,2	MCF-7	breast:
5	chr8:61599531..61602030-chr8:61683939..61686653,2	MCF-7	breast:
6	chr8:61676637..61679256-chr8:61683583..61686325,2	K562	blood:

Variant related genes	Relation type
ENSG00000254869	Chromatin interaction

Extended variants
information (count: 125 )
Associated
traits (count: 0)

rSNPs within LD-proxies of this variant (count:118)

rs_ID	r²[population]
rs10093135	0.90[AMR][1000 genomes];0.90[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs10103011	0.87[AMR][1000 genomes];0.96[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs10109193	0.87[AMR][1000 genomes];0.96[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs1038351	0.89[AMR][1000 genomes];0.93[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs1038352	0.89[AMR][1000 genomes];0.93[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs10448027	0.85[AMR][1000 genomes];0.96[EUR][1000 genomes]
rs10808711	0.90[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs10808712	0.90[CHB][hapmap];1.00[JPT][hapmap];0.86[ASN][1000 genomes]
rs10808713	1.00[CEU][hapmap];1.00[CHB][hapmap];1.00[JPT][hapmap];0.81[YRI][hapmap];0.84[AMR][1000 genomes];0.89[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs10957154	0.90[EUR][1000 genomes];0.81[ASN][1000 genomes]
rs10957155	0.90[EUR][1000 genomes];0.81[ASN][1000 genomes]
rs10957156	0.94[CEU][hapmap];0.90[CHB][hapmap];1.00[JPT][hapmap];0.89[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs10957158	0.98[AMR][1000 genomes];0.98[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs10957161	0.90[AMR][1000 genomes];0.97[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs10957162	0.82[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs11985638	0.95[CEU][hapmap];1.00[CHB][hapmap];1.00[JPT][hapmap];0.89[AMR][1000 genomes];0.93[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs11986059	0.82[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs11986742	0.88[AMR][1000 genomes];0.96[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs11988338	0.90[AMR][1000 genomes];0.97[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs11989183	0.82[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs11990495	0.91[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs11991467	0.95[AMR][1000 genomes];0.98[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs11992809	1.00[CEU][hapmap];1.00[CHB][hapmap];1.00[JPT][hapmap];0.87[AMR][1000 genomes];0.93[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs11993480	0.81[AFR][1000 genomes];0.86[AMR][1000 genomes];0.82[EUR][1000 genomes];0.93[ASN][1000 genomes]
rs11993490	0.90[AMR][1000 genomes];0.86[EUR][1000 genomes];0.93[ASN][1000 genomes]
rs11993896	0.88[AMR][1000 genomes];0.96[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs11995234	0.91[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs12544305	1.00[CEU][hapmap];0.89[CHB][hapmap];1.00[JPT][hapmap];0.90[EUR][1000 genomes];0.81[ASN][1000 genomes]
rs12681737	0.86[ASN][1000 genomes]
rs13255519	1.00[CEU][hapmap];1.00[CHB][hapmap];1.00[JPT][hapmap];0.87[AMR][1000 genomes];0.90[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs13264014	0.90[AMR][1000 genomes];0.90[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs13277976	0.80[AFR][1000 genomes];0.98[AMR][1000 genomes];0.98[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs1384688	1.00[CEU][hapmap];1.00[CHB][hapmap];1.00[JPT][hapmap];0.80[AFR][1000 genomes];0.98[AMR][1000 genomes];0.98[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs1483206	0.89[AMR][1000 genomes];0.90[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs16926407	0.81[ASN][1000 genomes]
rs1905305	0.90[AMR][1000 genomes];0.91[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs1964573	0.81[EUR][1000 genomes]
rs2035456	0.94[CEU][hapmap];0.88[CHB][hapmap];1.00[JPT][hapmap];0.90[EUR][1000 genomes];0.81[ASN][1000 genomes]
rs2035457	0.90[EUR][1000 genomes];0.81[ASN][1000 genomes]
rs2054666	0.80[AFR][1000 genomes];0.98[AMR][1000 genomes];0.98[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs2054667	0.80[AFR][1000 genomes];0.98[AMR][1000 genomes];0.98[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs2128713	0.94[CEU][hapmap];0.90[CHB][hapmap];1.00[JPT][hapmap];0.90[EUR][1000 genomes];0.81[ASN][1000 genomes]
rs2326598	0.93[AMR][1000 genomes];0.97[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs28653462	0.91[ASN][1000 genomes]
rs2875984	0.93[AMR][1000 genomes];0.96[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs4237037	0.82[AMR][1000 genomes];0.93[EUR][1000 genomes];0.86[ASN][1000 genomes]
rs4237038	0.80[AMR][1000 genomes];0.89[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs4289855	0.85[AMR][1000 genomes];0.96[EUR][1000 genomes]
rs4301480	0.85[AMR][1000 genomes];0.96[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs4307377	1.00[CHB][hapmap];0.81[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs4387010	0.82[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs4391471	0.88[AMR][1000 genomes];0.97[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs4392940	0.82[AMR][1000 genomes];0.98[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs4416857	0.82[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs4449834	1.00[CHB][hapmap]
rs4500113	0.80[AFR][1000 genomes];0.98[AMR][1000 genomes];0.98[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs4507803	0.82[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs4526395	0.82[CEU][hapmap];1.00[CHB][hapmap];0.82[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs4540437	0.85[AMR][1000 genomes];0.96[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs4562360	0.85[AMR][1000 genomes];0.96[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs4581092	0.87[AMR][1000 genomes];0.96[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs4737565	0.90[CEU][hapmap];1.00[CHB][hapmap];0.82[AMR][1000 genomes];0.89[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs4738815	0.94[CEU][hapmap];0.90[CHB][hapmap];1.00[JPT][hapmap];0.90[EUR][1000 genomes];0.81[ASN][1000 genomes]
rs4738818	0.94[CEU][hapmap];0.90[CHB][hapmap];1.00[JPT][hapmap];0.90[EUR][1000 genomes];0.86[ASN][1000 genomes]
rs4738820	0.82[AMR][1000 genomes];0.93[EUR][1000 genomes]
rs4738821	0.92[AMR][1000 genomes];0.97[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs4738822	0.80[AFR][1000 genomes];0.95[AMR][1000 genomes];0.98[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs4738824	0.90[AMR][1000 genomes];0.98[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs4738827	0.87[AMR][1000 genomes];0.96[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs4738831	1.00[CHB][hapmap]
rs4738832	1.00[CHB][hapmap];0.82[EUR][1000 genomes]
rs6471894	1.00[CEU][hapmap];0.89[CHB][hapmap];1.00[JPT][hapmap];0.90[EUR][1000 genomes];0.83[ASN][1000 genomes]
rs6471896	1.00[CEU][hapmap];0.89[CHB][hapmap];1.00[JPT][hapmap];0.90[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs6471897	0.84[AFR][1000 genomes];0.88[AMR][1000 genomes];0.85[EUR][1000 genomes];0.93[ASN][1000 genomes]
rs6471898	1.00[CEU][hapmap];1.00[CHB][hapmap];1.00[JPT][hapmap];0.84[AFR][1000 genomes];0.88[AMR][1000 genomes];0.85[EUR][1000 genomes];0.93[ASN][1000 genomes]
rs6471901	0.90[AMR][1000 genomes];0.98[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs6471902	0.82[AMR][1000 genomes];0.93[EUR][1000 genomes];0.86[ASN][1000 genomes]
rs6471903	0.94[CEU][hapmap];1.00[CHB][hapmap];0.82[AMR][1000 genomes];0.89[EUR][1000 genomes]
rs6471905	1.00[CHB][hapmap];0.80[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs6982898	0.87[AMR][1000 genomes];0.96[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs6988582	0.89[CEU][hapmap];0.91[EUR][1000 genomes]
rs6994180	0.89[AMR][1000 genomes];0.90[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs6995557	0.90[EUR][1000 genomes];0.81[ASN][1000 genomes]
rs6996597	0.82[AMR][1000 genomes];0.92[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs6996775	0.81[AMR][1000 genomes];0.88[EUR][1000 genomes]
rs6997208	0.82[AMR][1000 genomes];0.92[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs6997222	0.82[AMR][1000 genomes];0.87[EUR][1000 genomes]
rs7000766	1.00[CEU][hapmap];1.00[CHB][hapmap];1.00[JPT][hapmap];0.87[AMR][1000 genomes];0.90[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs7000957	0.85[AMR][1000 genomes];0.96[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs7002806	0.80[AFR][1000 genomes];0.98[AMR][1000 genomes];0.98[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs7005873	1.00[CHB][hapmap];0.81[EUR][1000 genomes]
rs7009754	0.90[AMR][1000 genomes];0.98[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs7011972	1.00[CEU][hapmap];0.89[CHB][hapmap];1.00[JPT][hapmap];0.90[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs7012450	0.87[AMR][1000 genomes];0.89[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs7016832	0.82[AMR][1000 genomes];0.86[EUR][1000 genomes]
rs7017676	0.93[AMR][1000 genomes];0.98[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs730085	1.00[CEU][hapmap];1.00[CHB][hapmap];1.00[JPT][hapmap];0.86[AMR][1000 genomes];0.89[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs7814114	0.83[AFR][1000 genomes];0.86[EUR][1000 genomes];0.93[ASN][1000 genomes]
rs7816126	0.81[AFR][1000 genomes];0.88[AMR][1000 genomes];0.86[EUR][1000 genomes];0.93[ASN][1000 genomes]
rs7816621	0.89[CEU][hapmap];0.89[CHB][hapmap];1.00[JPT][hapmap];0.81[ASN][1000 genomes]
rs7823484	0.93[AMR][1000 genomes];0.97[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs7826035	0.94[CEU][hapmap];0.90[CHB][hapmap];1.00[JPT][hapmap];0.90[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs7834076	0.82[AMR][1000 genomes];0.83[EUR][1000 genomes]
rs7834977	0.88[CHB][hapmap];0.82[AMR][1000 genomes];0.93[EUR][1000 genomes];0.93[ASN][1000 genomes]
rs7836586	0.94[CEU][hapmap];1.00[CHB][hapmap];1.00[JPT][hapmap];0.89[AMR][1000 genomes];0.90[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs7838426	0.87[AMR][1000 genomes];0.92[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs7840098	0.95[CEU][hapmap];1.00[CHB][hapmap];1.00[JPT][hapmap];0.90[AMR][1000 genomes];0.96[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs7842389	1.00[CEU][hapmap];1.00[CHB][hapmap];1.00[JPT][hapmap];0.80[AFR][1000 genomes];0.98[AMR][1000 genomes];0.98[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs7842498	1.00[CEU][hapmap];1.00[CHB][hapmap];1.00[JPT][hapmap];1.00[YRI][hapmap];1.00[AFR][1000 genomes];1.00[AMR][1000 genomes];0.99[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs7843033	0.90[AMR][1000 genomes];0.93[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs7844902	0.82[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs7845701	0.93[CEU][hapmap];1.00[JPT][hapmap];0.90[EUR][1000 genomes];0.86[ASN][1000 genomes]
rs7846065	0.90[AMR][1000 genomes];0.90[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs900502	0.94[CEU][hapmap];0.90[CHB][hapmap];1.00[JPT][hapmap];0.90[EUR][1000 genomes];0.81[ASN][1000 genomes]
rs9298040	0.90[AMR][1000 genomes];0.90[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs9298042	0.90[AMR][1000 genomes];0.96[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs9643371	0.90[CHB][hapmap];1.00[JPT][hapmap];0.81[ASN][1000 genomes]
rs9650201	0.90[AMR][1000 genomes];0.92[EUR][1000 genomes];0.98[ASN][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:7 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv917756	chr8:60942299-61862796	Enhancers Weak transcription Active TSS Genic enhancers Bivalent/Poised TSS Strong transcription Bivalent Enhancer Flanking Active TSS Flanking Bivalent TSS/Enh ZNF genes & repeats Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	74 gene(s)	inside rSNPs	diseases
2	nsv831335	chr8:61497540-61688992	Weak transcription Strong transcription Flanking Active TSS Enhancers Bivalent Enhancer Active TSS Bivalent/Poised TSS Genic enhancers Flanking Bivalent TSS/Enh ZNF genes & repeats Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	33 gene(s)	inside rSNPs	diseases
3	nsv890945	chr8:61522008-61707725	Weak transcription Genic enhancers Strong transcription Enhancers Flanking Active TSS Active TSS Bivalent/Poised TSS Flanking Bivalent TSS/Enh Bivalent Enhancer Transcr. at gene 5' and 3' ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	33 gene(s)	inside rSNPs	diseases
4	nsv526196	chr8:61593569-61877623	Weak transcription Enhancers Strong transcription Flanking Active TSS Genic enhancers Bivalent/Poised TSS ZNF genes & repeats Active TSS Bivalent Enhancer Flanking Bivalent TSS/Enh Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	11 gene(s)	inside rSNPs	diseases
5	nsv1022801	chr8:61623974-61738067	Weak transcription Strong transcription Enhancers Flanking Active TSS Genic enhancers Active TSS ZNF genes & repeats Bivalent Enhancer Bivalent/Poised TSS Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	7 gene(s)	inside rSNPs	diseases
6	nsv539632	chr8:61623974-61738067	Weak transcription Enhancers Strong transcription Active TSS ZNF genes & repeats Genic enhancers Flanking Active TSS Bivalent Enhancer Bivalent/Poised TSS Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	7 gene(s)	inside rSNPs	diseases
7	esv1797364	chr8:61658362-61696231	Weak transcription Genic enhancers Enhancers Strong transcription Flanking Active TSS Active TSS Bivalent Enhancer ZNF genes & repeats Transcr. at gene 5' and 3'	Chromatin interactive region	3 gene(s)	inside rSNPs	diseases

No data

Chromatin state (count:94 , 50 per page) page: 1 2

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr8:61657000-61690400	Weak transcription	HepG2	liver
2	chr8:61672000-61694400	Weak transcription	A549	lung
3	chr8:61672200-61693400	Weak transcription	Hela-S3	cervix
4	chr8:61672200-61694000	Weak transcription	HUVEC	blood vessel
5	chr8:61672600-61685400	Weak transcription	H1 Derived Neuronal Progenitor Cultured Cells	ES cell derived
6	chr8:61675000-61687000	Weak transcription	Fetal Stomach	stomach
7	chr8:61676400-61687000	Weak transcription	H1 Derived Mesenchymal Stem Cells	ES cell derived
8	chr8:61677000-61691800	Enhancers	Ganglion Eminence derived primary cultured neurospheres	brain
9	chr8:61678000-61687600	Enhancers	Primary B cells from peripheral blood	blood
10	chr8:61678400-61687400	Enhancers	Primary T helper naive cells fromperipheralblood	blood
11	chr8:61678400-61687600	Enhancers	Primary T helper cells PMA-I stimulated	--
12	chr8:61678800-61687600	Enhancers	Brain Germinal Matrix	brain
13	chr8:61679000-61686800	Enhancers	Primary T helper cells fromperipheralblood	blood
14	chr8:61679600-61687200	Enhancers	HUES64 Cell Line	embryonic stem cell
15	chr8:61679600-61688200	Enhancers	Fetal Lung	lung
16	chr8:61680000-61698600	Weak transcription	Brain Dorsolateral Prefrontal Cortex	brain
17	chr8:61680200-61685600	Weak transcription	Breast Myoepithelial Primary Cells	Breast
18	chr8:61680200-61686000	Weak transcription	ES-WA7 Cell Line	embryonic stem cell
19	chr8:61680200-61686600	Weak transcription	Fetal Brain Male	brain
20	chr8:61680200-61694800	Weak transcription	Lung	lung
21	chr8:61680200-61694800	Weak transcription	K562	blood
22	chr8:61680200-61696200	Weak transcription	Foreskin Melanocyte Primary Cells skin01	Skin
23	chr8:61680200-61704200	Weak transcription	Primary mononuclear cells fromperipheralblood	Blood
24	chr8:61680200-61705200	Weak transcription	Esophagus	oesophagus
25	chr8:61680200-61710400	Weak transcription	Pancreas	Pancrea
26	chr8:61680400-61685600	Weak transcription	iPS DF 6.9 Cell Line	embryonic stem cell
27	chr8:61680400-61686000	Weak transcription	Mesenchymal Stem Cell Derived Chondrocyte Cultured Cells	embryonic stem cell
28	chr8:61680400-61686800	Weak transcription	Skeletal Muscle Female	skeletal muscle
29	chr8:61680400-61689400	Weak transcription	Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	ES cell derived
30	chr8:61680400-61694600	Weak transcription	Placenta	Placenta
31	chr8:61681000-61694400	Weak transcription	HSMMtube	muscle
32	chr8:61681200-61685000	Weak transcription	H1 BMP4 Derived Trophoblast Cultured Cells	ES cell derived
33	chr8:61681200-61685200	Weak transcription	hESC Derived CD56+ Ectoderm Cultured Cells	ES cell derived
34	chr8:61681200-61685400	Weak transcription	Primary neutrophils fromperipheralblood	blood
35	chr8:61681200-61686600	Weak transcription	Primary T cells fromperipheralblood	blood
36	chr8:61681200-61686600	Weak transcription	Left Ventricle	heart
37	chr8:61681200-61693600	Weak transcription	Fetal Muscle Trunk	muscle
38	chr8:61681200-61693600	Weak transcription	Fetal Muscle Leg	muscle
39	chr8:61681200-61694800	Weak transcription	Gastric	stomach
40	chr8:61681200-61696200	Weak transcription	Right Ventricle	heart
41	chr8:61681200-61698600	Weak transcription	Primary hematopoietic stem cells short term culture	blood
42	chr8:61681200-61700400	Weak transcription	iPS DF 19.11 Cell Line	embryonic stem cell
43	chr8:61681200-61705200	Weak transcription	Spleen	Spleen
44	chr8:61681400-61685000	Weak transcription	HSMM	muscle
45	chr8:61681400-61693600	Weak transcription	Dnd41	blood
46	chr8:61681800-61685400	Weak transcription	ES-UCSF4 Cell Line	embryonic stem cell
47	chr8:61682000-61685600	Weak transcription	Fetal Intestine Small	intestine
48	chr8:61682200-61684800	Weak transcription	hESC Derived CD56+ Mesoderm Cultured Cells	ES cell derived
49	chr8:61682200-61685200	Enhancers	Primary T killer memory cells from peripheral blood	blood
50	chr8:61682200-61705200	Weak transcription	Skeletal Muscle Male	skeletal muscle

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