Variant report

Variant	rs946711
Chromosome Location	chr10:21806832-21806833
allele	A/C
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Distal block	Cell Line	Cell type
1	chr10:21783306..21788486-chr10:21805319..21811721,9	K562	blood:
2	chr10:21805605..21807805-chr10:21851609..21854226,2	MCF-7	breast:
3	chr10:21783475..21788073-chr10:21802793..21808915,11	MCF-7	breast:

Variant related genes	Relation type
ENSG00000222071	Chromatin interaction
ENSG00000204682	Chromatin interaction
ENSG00000207347	Chromatin interaction

Extended variants
information (count: 43 )
Associated
traits (count: 1 )

rSNPs within LD-proxies of this variant (count:19)

rs_ID	r²[population]
rs10828247	0.80[TSI][hapmap]
rs10828248	0.82[TSI][hapmap]
rs10828249	0.82[TSI][hapmap]
rs10828250	0.80[EUR][1000 genomes]
rs10828252	1.00[CHB][hapmap]
rs11012725	0.80[AMR][1000 genomes]
rs11012726	0.86[AMR][1000 genomes];0.85[EUR][1000 genomes]
rs11012737	1.00[CHB][hapmap];0.86[TSI][hapmap]
rs12357321	0.90[CEU][hapmap];1.00[CHB][hapmap];0.89[AMR][1000 genomes];0.83[EUR][1000 genomes]
rs1243194	1.00[CHB][hapmap]
rs1243195	1.00[CHB][hapmap]
rs1269454	1.00[CHB][hapmap]
rs12770228	1.00[CHB][hapmap];0.94[GIH][hapmap];0.86[MEX][hapmap];0.91[TSI][hapmap];0.85[AMR][1000 genomes];0.85[EUR][1000 genomes]
rs16921773	1.00[CHB][hapmap]
rs16921779	1.00[CHB][hapmap]
rs2026092	1.00[CHB][hapmap]
rs34853448	0.83[AMR][1000 genomes];0.87[EUR][1000 genomes];0.92[ASN][1000 genomes]
rs7084454	0.81[CEU][hapmap];1.00[CHB][hapmap]
rs7098100	0.82[TSI][hapmap]

Variant overlapped rSNPs/rCNVs (count:24 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv825284	chr10:21739527-21847437	Active TSS Weak transcription Flanking Active TSS Flanking Bivalent TSS/Enh Strong transcription Bivalent/Poised TSS Enhancers Bivalent Enhancer Genic enhancers Transcr. at gene 5' and 3' ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA	34 gene(s)	inside rSNPs	diseases
2	nsv825285	chr10:21742026-21874334	Strong transcription Weak transcription Active TSS Flanking Bivalent TSS/Enh Flanking Active TSS Bivalent/Poised TSS Enhancers Bivalent Enhancer Transcr. at gene 5' and 3' Genic enhancers ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA	34 gene(s)	inside rSNPs	diseases
3	nsv825286	chr10:21757784-21838890	Flanking Active TSS Bivalent/Poised TSS Weak transcription Active TSS Enhancers Flanking Bivalent TSS/Enh Bivalent Enhancer Genic enhancers Strong transcription Transcr. at gene 5' and 3' ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA	34 gene(s)	inside rSNPs	diseases
4	nsv825288	chr10:21759085-21831354	Flanking Active TSS Bivalent Enhancer Flanking Bivalent TSS/Enh Bivalent/Poised TSS Active TSS Enhancers Strong transcription Weak transcription Genic enhancers Transcr. at gene 5' and 3' ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA	34 gene(s)	inside rSNPs	diseases
5	nsv825289	chr10:21762506-21845875	Strong transcription Enhancers Active TSS Bivalent/Poised TSS Flanking Active TSS Weak transcription Bivalent Enhancer Genic enhancers Flanking Bivalent TSS/Enh Transcr. at gene 5' and 3' ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA	34 gene(s)	inside rSNPs	diseases
6	nsv527055	chr10:21764019-21822856	Bivalent/Poised TSS Weak transcription Flanking Active TSS Enhancers Flanking Bivalent TSS/Enh Active TSS Bivalent Enhancer Genic enhancers Transcr. at gene 5' and 3' Strong transcription ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA	34 gene(s)	inside rSNPs	diseases
7	nsv825290	chr10:21777857-21830878	Active TSS Flanking Active TSS Weak transcription Flanking Bivalent TSS/Enh Bivalent Enhancer Strong transcription Bivalent/Poised TSS Enhancers Genic enhancers Transcr. at gene 5' and 3' ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA	33 gene(s)	inside rSNPs	diseases
8	nsv894936	chr10:21781589-21827796	Active TSS Bivalent/Poised TSS Weak transcription Flanking Active TSS Bivalent Enhancer Flanking Bivalent TSS/Enh Enhancers Genic enhancers Transcr. at gene 5' and 3' Strong transcription ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA	33 gene(s)	inside rSNPs	diseases
9	nsv550200	chr10:21782842-21824727	Active TSS Bivalent/Poised TSS Enhancers Flanking Active TSS Flanking Bivalent TSS/Enh Bivalent Enhancer Weak transcription Strong transcription ZNF genes & repeats Transcr. at gene 5' and 3' Genic enhancers	TF binding region CpG island Chromatin interactive region lncRNA miRNA	33 gene(s)	inside rSNPs	diseases
10	nsv894937	chr10:21782842-21827796	Enhancers Transcr. at gene 5' and 3' Flanking Active TSS Active TSS Flanking Bivalent TSS/Enh Bivalent/Poised TSS Weak transcription Bivalent Enhancer Strong transcription Genic enhancers ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA	33 gene(s)	inside rSNPs	diseases
11	nsv517469	chr10:21783634-21822856	Active TSS Bivalent Enhancer Flanking Active TSS Weak transcription Enhancers Bivalent/Poised TSS Flanking Bivalent TSS/Enh Transcr. at gene 5' and 3' Genic enhancers ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA	33 gene(s)	inside rSNPs	diseases
12	nsv894938	chr10:21784899-21827796	Enhancers Flanking Active TSS Active TSS Weak transcription Bivalent/Poised TSS Flanking Bivalent TSS/Enh Bivalent Enhancer Strong transcription Transcr. at gene 5' and 3' Genic enhancers ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA	33 gene(s)	inside rSNPs	diseases
13	nsv894939	chr10:21789406-21830104	Bivalent Enhancer Enhancers Active TSS Flanking Active TSS Bivalent/Poised TSS Weak transcription Flanking Bivalent TSS/Enh Strong transcription Transcr. at gene 5' and 3' Genic enhancers ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA	26 gene(s)	inside rSNPs	diseases
14	nsv825291	chr10:21792100-21830946	Active TSS Flanking Active TSS Enhancers Flanking Bivalent TSS/Enh Weak transcription Strong transcription Bivalent Enhancer Bivalent/Poised TSS Genic enhancers Transcr. at gene 5' and 3' ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA	26 gene(s)	inside rSNPs	diseases
15	nsv894940	chr10:21796081-21823525	Active TSS Flanking Active TSS Weak transcription Enhancers Flanking Bivalent TSS/Enh Bivalent/Poised TSS Bivalent Enhancer Genic enhancers Transcr. at gene 5' and 3' ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA	26 gene(s)	inside rSNPs	diseases
16	nsv550201	chr10:21796081-21824727	Weak transcription Active TSS Flanking Bivalent TSS/Enh Flanking Active TSS Bivalent/Poised TSS Enhancers Bivalent Enhancer Transcr. at gene 5' and 3' Genic enhancers ZNF genes & repeats Strong transcription	TF binding region CpG island Chromatin interactive region lncRNA	26 gene(s)	inside rSNPs	diseases
17	nsv894941	chr10:21796081-21827796	Weak transcription Enhancers Active TSS Strong transcription Flanking Active TSS Flanking Bivalent TSS/Enh Bivalent Enhancer Bivalent/Poised TSS Transcr. at gene 5' and 3' Genic enhancers ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA	26 gene(s)	inside rSNPs	diseases
18	nsv894942	chr10:21798241-21823525	Flanking Active TSS Active TSS Enhancers Weak transcription Flanking Bivalent TSS/Enh Bivalent/Poised TSS Bivalent Enhancer Transcr. at gene 5' and 3' ZNF genes & repeats Genic enhancers	TF binding region CpG island Chromatin interactive region lncRNA	26 gene(s)	inside rSNPs	diseases
19	nsv894943	chr10:21798241-21824619	Active TSS Flanking Bivalent TSS/Enh Enhancers Flanking Active TSS Weak transcription Bivalent Enhancer Bivalent/Poised TSS Transcr. at gene 5' and 3' Genic enhancers ZNF genes & repeats Strong transcription	TF binding region CpG island Chromatin interactive region lncRNA	26 gene(s)	inside rSNPs	diseases
20	nsv894944	chr10:21798241-21827796	Flanking Active TSS Active TSS Weak transcription Bivalent Enhancer Enhancers Strong transcription Flanking Bivalent TSS/Enh Transcr. at gene 5' and 3' Genic enhancers Bivalent/Poised TSS ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA	26 gene(s)	inside rSNPs	diseases
21	nsv894945	chr10:21798241-21830104	Active TSS Bivalent Enhancer Enhancers Weak transcription Flanking Active TSS Strong transcription Transcr. at gene 5' and 3' Bivalent/Poised TSS Flanking Bivalent TSS/Enh Genic enhancers ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA	26 gene(s)	inside rSNPs	diseases
22	nsv894946	chr10:21798241-21831215	Enhancers Bivalent/Poised TSS Weak transcription Flanking Active TSS Strong transcription Genic enhancers Active TSS Flanking Bivalent TSS/Enh Bivalent Enhancer Transcr. at gene 5' and 3' ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA	26 gene(s)	inside rSNPs	diseases
23	esv3436763	chr10:21804771-21807819	Active TSS Flanking Active TSS Bivalent/Poised TSS Bivalent Enhancer Flanking Bivalent TSS/Enh Weak transcription Transcr. at gene 5' and 3' Enhancers	TF binding region CpG island Chromatin interactive region	4 gene(s)	inside rSNPs	n/a
24	esv3441326	chr10:21805146-21807294	Flanking Bivalent TSS/Enh Active TSS Bivalent Enhancer Bivalent/Poised TSS Flanking Active TSS Weak transcription Enhancers Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region	4 gene(s)	inside rSNPs	n/a

mRNA abundance (count:1)

SNP	Gene	Cis/trans	Tissue	Source
rs946711	MLLT10	Cis_1M	lymphoblastoid	RTeQTL

Chromatin state (count:122 , 50 per page) page: 1 2 3

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr10:21801000-21809200	Active TSS	H1 Derived Neuronal Progenitor Cultured Cells	ES cell derived
2	chr10:21802800-21807000	Active TSS	hESC Derived CD56+ Mesoderm Cultured Cells	ES cell derived
3	chr10:21803200-21809200	Active TSS	Colon Smooth Muscle	Colon
4	chr10:21803400-21808200	Active TSS	H1 BMP4 Derived Mesendoderm Cultured Cells	ES cell derived
5	chr10:21803600-21808000	Active TSS	Fetal Lung	lung
6	chr10:21803600-21808600	Bivalent/Poised TSS	Duodenum Smooth Muscle	Duodenum
7	chr10:21804000-21809600	Active TSS	Right Ventricle	heart
8	chr10:21804200-21809400	Active TSS	Brain Inferior Temporal Lobe	brain
9	chr10:21804200-21809400	Active TSS	Left Ventricle	heart
10	chr10:21804400-21808000	Active TSS	Brain Substantia Nigra	brain
11	chr10:21804400-21808000	Active TSS	Fetal Kidney	kidney
12	chr10:21804400-21808200	Active TSS	Placenta Amnion	Placenta Amnion
13	chr10:21804400-21809400	Active TSS	Brain Cingulate Gyrus	brain
14	chr10:21804400-21809600	Active TSS	Ovary	ovary
15	chr10:21804600-21809600	Active TSS	Brain Germinal Matrix	brain
16	chr10:21804800-21807600	Active TSS	Ganglion Eminence derived primary cultured neurospheres	brain
17	chr10:21804800-21808000	Active TSS	Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	ES cell derived
18	chr10:21804800-21808200	Active TSS	HUES64 Cell Line	embryonic stem cell
19	chr10:21804800-21808400	Active TSS	ES-WA7 Cell Line	embryonic stem cell
20	chr10:21804800-21809600	Active TSS	Pancreatic Islets	Pancreatic Islet
21	chr10:21805000-21807000	Active TSS	ES-I3 Cell Line	embryonic stem cell
22	chr10:21805000-21807000	Bivalent/Poised TSS	iPS-15b Cell Line	embryonic stem cell
23	chr10:21805000-21808000	Active TSS	Cortex derived primary cultured neurospheres	brain
24	chr10:21805000-21808000	Active TSS	Fetal Stomach	stomach
25	chr10:21805000-21808200	Active TSS	H1 BMP4 Derived Trophoblast Cultured Cells	ES cell derived
26	chr10:21805000-21809400	Active TSS	Brain Angular Gyrus	brain
27	chr10:21805000-21809400	Active TSS	Brain Anterior Caudate	brain
28	chr10:21805000-21809400	Active TSS	Brain Dorsolateral Prefrontal Cortex	brain
29	chr10:21805000-21809600	Active TSS	Aorta	Aorta
30	chr10:21805000-21809600	Active TSS	NHDF-Ad	bronchial
31	chr10:21805200-21807000	Active TSS	Lung	lung
32	chr10:21805200-21807800	Active TSS	A549	lung
33	chr10:21805200-21808200	Active TSS	iPS DF 6.9 Cell Line	embryonic stem cell
34	chr10:21805200-21808200	Active TSS	Brain Hippocampus Middle	brain
35	chr10:21805200-21809600	Active TSS	IMR90 fetal lung fibroblasts Cell Line	lung
36	chr10:21805200-21809600	Active TSS	Psoas Muscle	Psoas
37	chr10:21805200-21810000	Active TSS	Foreskin Fibroblast Primary Cells skin01	Skin
38	chr10:21805400-21808000	Active TSS	Foreskin Melanocyte Primary Cells skin01	Skin
39	chr10:21805400-21809200	Active TSS	Esophagus	oesophagus
40	chr10:21805400-21809400	Active TSS	Foreskin Fibroblast Primary Cells skin02	Skin
41	chr10:21805400-21809400	Active TSS	Foreskin Keratinocyte Primary Cells skin02	Skin
42	chr10:21805400-21809800	Active TSS	hESC Derived CD56+ Ectoderm Cultured Cells	ES cell derived
43	chr10:21805600-21807000	Active TSS	NHLF	lung
44	chr10:21805600-21807800	Active TSS	H9 Derived Neuron Cultured Cells	ES cell derived
45	chr10:21805600-21809200	Active TSS	Pancreas	Pancrea
46	chr10:21805600-21809400	Active TSS	Fetal Muscle Trunk	muscle
47	chr10:21805800-21808200	Active TSS	H9 Derived Neuronal Progenitor Cultured Cells	ES cell derived
48	chr10:21806000-21809600	Active TSS	Right Atrium	heart
49	chr10:21806200-21807000	Flanking Bivalent TSS/Enh	Primary B cells from cord blood	blood
50	chr10:21806200-21807000	Flanking Bivalent TSS/Enh	Primary T helper cells fromperipheralblood	blood

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