Variant report

Variant	rs10276077
Chromosome Location	chr7:65728411-65728412
allele	A/G
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Distal block	Cell Line	Cell type	Cell Stage
1	chr7:65728235..65729776-chr7:65732042..65733937,2	MCF-7	breast:

Extended variants
information (count: 135 )
Associated
traits (count: 18 )

rSNPs within LD-proxies of this variant (count:130)

rs_ID	r²[population]
rs1000464	0.90[AFR][1000 genomes];0.97[AMR][1000 genomes];0.97[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs10215948	0.83[AMR][1000 genomes]
rs10224872	0.90[AFR][1000 genomes];0.98[AMR][1000 genomes];0.99[EUR][1000 genomes];0.92[ASN][1000 genomes]
rs10228885	0.82[AFR][1000 genomes];0.82[AMR][1000 genomes];0.93[EUR][1000 genomes]
rs10240249	0.80[EUR][1000 genomes]
rs10240949	0.81[AFR][1000 genomes];0.94[AMR][1000 genomes];0.98[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs10250544	0.82[AFR][1000 genomes];0.81[AMR][1000 genomes];0.93[EUR][1000 genomes]
rs10255397	0.87[AMR][1000 genomes];0.94[EUR][1000 genomes];0.85[ASN][1000 genomes]
rs10256544	0.84[AFR][1000 genomes];0.89[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs10257427	0.83[AMR][1000 genomes]
rs10257911	0.82[AFR][1000 genomes];0.85[AMR][1000 genomes];0.91[EUR][1000 genomes]
rs10260426	0.86[AFR][1000 genomes];0.86[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs10261398	0.90[AFR][1000 genomes];1.00[AMR][1000 genomes];0.99[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs10263690	0.82[AFR][1000 genomes];0.83[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs10267430	0.83[AMR][1000 genomes]
rs10272149	0.84[EUR][1000 genomes]
rs10282433	0.97[AFR][1000 genomes];0.99[AMR][1000 genomes];0.99[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs10447522	0.81[AFR][1000 genomes];0.81[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs10807704	0.84[EUR][1000 genomes]
rs1083554	0.86[EUR][1000 genomes]
rs10950033	0.92[AFR][1000 genomes];1.00[AMR][1000 genomes];0.99[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs1129531	0.80[EUR][1000 genomes]
rs11760844	0.92[AFR][1000 genomes];1.00[AMR][1000 genomes];0.99[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs11764589	0.85[EUR][1000 genomes]
rs11769079	0.86[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs11984115	0.83[AMR][1000 genomes];0.93[EUR][1000 genomes]
rs12531677	0.83[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs12534500	0.89[EUR][1000 genomes]
rs12537823	0.97[AFR][1000 genomes];1.00[AMR][1000 genomes];0.99[EUR][1000 genomes];0.93[ASN][1000 genomes]
rs13225672	0.84[AMR][1000 genomes];0.85[EUR][1000 genomes]
rs13230545	0.84[AFR][1000 genomes];0.86[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs13309935	0.82[AFR][1000 genomes];0.85[AMR][1000 genomes];0.93[EUR][1000 genomes]
rs1532571	0.82[AFR][1000 genomes];0.86[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs1643375	0.83[AMR][1000 genomes];0.88[EUR][1000 genomes]
rs1695820	0.84[EUR][1000 genomes]
rs1875057	0.86[AFR][1000 genomes];0.86[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs2036263	0.83[AFR][1000 genomes];0.94[AMR][1000 genomes];0.98[EUR][1000 genomes];0.88[ASN][1000 genomes]
rs2036264	0.81[AFR][1000 genomes]
rs2088653	0.80[AMR][1000 genomes];0.93[EUR][1000 genomes]
rs2088655	0.81[AFR][1000 genomes];0.81[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs2173570	0.88[AFR][1000 genomes];0.82[AMR][1000 genomes]
rs2420173	0.82[AMR][1000 genomes];0.84[EUR][1000 genomes]
rs2420174	0.82[AMR][1000 genomes];0.84[EUR][1000 genomes]
rs2420608	0.83[EUR][1000 genomes]
rs28391294	0.81[AMR][1000 genomes];0.82[EUR][1000 genomes]
rs28491091	0.90[EUR][1000 genomes]
rs2901152	0.82[AFR][1000 genomes];0.82[AMR][1000 genomes];0.93[EUR][1000 genomes]
rs2901155	0.81[AMR][1000 genomes];0.85[EUR][1000 genomes]
rs2909688	0.91[EUR][1000 genomes]
rs34913718	0.87[EUR][1000 genomes]
rs3893216	0.81[AFR][1000 genomes];0.81[AMR][1000 genomes];0.91[EUR][1000 genomes]
rs3935391	0.81[AMR][1000 genomes]
rs4078376	0.85[AFR][1000 genomes];0.97[AMR][1000 genomes];0.99[EUR][1000 genomes];0.88[ASN][1000 genomes]
rs4149461	0.94[AFR][1000 genomes];1.00[AMR][1000 genomes];0.99[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs4236208	0.91[AFR][1000 genomes];0.99[AMR][1000 genomes];0.99[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs4587224	0.97[AFR][1000 genomes];1.00[AMR][1000 genomes];0.99[EUR][1000 genomes];0.96[ASN][1000 genomes]
rs4623294	0.86[AMR][1000 genomes];0.87[EUR][1000 genomes];0.83[ASN][1000 genomes]
rs4718319	0.84[AMR][1000 genomes];0.84[EUR][1000 genomes]
rs4718324	0.87[EUR][1000 genomes]
rs4718328	0.86[AFR][1000 genomes];0.95[AMR][1000 genomes];0.96[EUR][1000 genomes]
rs4718329	0.87[EUR][1000 genomes]
rs4718330	0.94[AFR][1000 genomes];0.95[AMR][1000 genomes];0.98[EUR][1000 genomes]
rs55748098	0.81[AMR][1000 genomes]
rs6460278	0.90[EUR][1000 genomes]
rs6460279	0.90[EUR][1000 genomes]
rs6460282	0.80[AMR][1000 genomes];0.91[EUR][1000 genomes]
rs6460284	0.83[AFR][1000 genomes];0.87[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs6460287	0.82[AMR][1000 genomes];0.93[EUR][1000 genomes]
rs6460290	0.94[AMR][1000 genomes];0.98[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs6460293	0.80[AMR][1000 genomes];0.93[EUR][1000 genomes]
rs6460301	0.80[EUR][1000 genomes]
rs6460302	0.82[EUR][1000 genomes]
rs6460304	0.81[EUR][1000 genomes]
rs6944374	0.81[AMR][1000 genomes];0.91[EUR][1000 genomes]
rs6945843	0.81[AMR][1000 genomes]
rs6951503	0.85[AFR][1000 genomes];0.86[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs6952182	0.81[AMR][1000 genomes];0.91[EUR][1000 genomes]
rs6952473	0.81[AMR][1000 genomes];0.87[EUR][1000 genomes]
rs6958294	0.81[AFR][1000 genomes];0.81[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs6959268	0.81[AFR][1000 genomes];0.94[AMR][1000 genomes];0.97[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs6960446	0.86[AFR][1000 genomes];0.86[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs6962717	0.80[AMR][1000 genomes];0.88[EUR][1000 genomes]
rs6963228	0.84[EUR][1000 genomes]
rs6964437	0.81[AMR][1000 genomes];0.91[EUR][1000 genomes]
rs6967708	0.84[AMR][1000 genomes];0.84[EUR][1000 genomes]
rs6971509	0.92[AFR][1000 genomes]
rs6971752	0.94[AFR][1000 genomes];0.99[AMR][1000 genomes];0.99[EUR][1000 genomes];0.96[ASN][1000 genomes]
rs6974614	0.93[AMR][1000 genomes];0.90[EUR][1000 genomes]
rs6976714	0.83[AMR][1000 genomes];0.87[EUR][1000 genomes]
rs6977501	0.84[AFR][1000 genomes]
rs6978028	0.84[EUR][1000 genomes]
rs6979452	0.92[EUR][1000 genomes]
rs6980451	0.82[EUR][1000 genomes]
rs709596	0.90[AMR][1000 genomes];0.98[EUR][1000 genomes];0.85[ASN][1000 genomes]
rs71526537	0.85[EUR][1000 genomes]
rs7778322	0.84[EUR][1000 genomes]
rs7781880	0.89[AMR][1000 genomes];0.90[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs7782704	0.83[AFR][1000 genomes];0.94[AMR][1000 genomes];0.98[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs7782806	0.84[AMR][1000 genomes];0.84[EUR][1000 genomes]
rs7783613	0.81[AFR][1000 genomes]
rs7783779	0.82[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs778680	0.90[AMR][1000 genomes];0.97[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs778684	0.91[AMR][1000 genomes];0.98[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs778686	0.89[AMR][1000 genomes];0.98[EUR][1000 genomes];0.83[ASN][1000 genomes]
rs7786892	0.81[EUR][1000 genomes]
rs778690	0.84[EUR][1000 genomes]
rs778697	0.84[EUR][1000 genomes]
rs778702	0.82[AMR][1000 genomes];0.88[EUR][1000 genomes]
rs778703	0.86[EUR][1000 genomes]
rs778705	0.85[EUR][1000 genomes]
rs778707	0.85[EUR][1000 genomes]
rs778711	0.85[EUR][1000 genomes]
rs778715	0.85[AMR][1000 genomes];0.92[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs778716	0.85[AMR][1000 genomes];0.92[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs778719	0.84[AMR][1000 genomes];0.85[EUR][1000 genomes]
rs778720	0.85[AMR][1000 genomes];0.92[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs778724	0.91[AMR][1000 genomes];0.98[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs778728	0.91[AMR][1000 genomes];0.95[EUR][1000 genomes]
rs778734	0.83[AFR][1000 genomes];0.93[AMR][1000 genomes];0.98[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs778736	0.81[AFR][1000 genomes];0.93[EUR][1000 genomes]
rs7787482	0.87[EUR][1000 genomes]
rs7789615	0.82[EUR][1000 genomes]
rs7794930	0.88[AFR][1000 genomes];0.82[AMR][1000 genomes]
rs7796162	0.82[AFR][1000 genomes];0.86[AMR][1000 genomes];0.92[EUR][1000 genomes]
rs7798630	0.83[AMR][1000 genomes];0.94[EUR][1000 genomes]
rs809025	0.85[AMR][1000 genomes];0.91[EUR][1000 genomes];0.81[ASN][1000 genomes]
rs880166	0.82[AFR][1000 genomes];0.85[AMR][1000 genomes];0.93[EUR][1000 genomes]
rs937495	0.88[AFR][1000 genomes];0.81[AMR][1000 genomes]
rs949930	0.90[AFR][1000 genomes];0.98[AMR][1000 genomes];0.99[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs9969301	0.81[AMR][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:5 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv532124	chr7:65371521-66234730	Enhancers Strong transcription Active TSS Weak transcription Flanking Active TSS Genic enhancers ZNF genes & repeats Bivalent/Poised TSS Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh Bivalent Enhancer	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	125 gene(s)	inside rSNPs	diseases
2	nsv1026559	chr7:65617368-66370805	Weak transcription Enhancers Flanking Active TSS Strong transcription Active TSS ZNF genes & repeats Genic enhancers Bivalent/Poised TSS Bivalent Enhancer Flanking Bivalent TSS/Enh Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	116 gene(s)	inside rSNPs	diseases
3	nsv1028692	chr7:65673136-65751069	Enhancers Weak transcription Strong transcription ZNF genes & repeats Genic enhancers Flanking Active TSS Active TSS Transcr. at gene 5' and 3' Bivalent/Poised TSS Bivalent Enhancer	TF binding region CpG island Chromatin interactive region lncRNA	1 gene(s)	inside rSNPs	diseases
4	nsv538908	chr7:65673136-65751069	Weak transcription Enhancers ZNF genes & repeats Strong transcription Genic enhancers Flanking Active TSS Bivalent/Poised TSS Active TSS Transcr. at gene 5' and 3' Bivalent Enhancer	TF binding region CpG island Chromatin interactive region lncRNA	1 gene(s)	inside rSNPs	diseases
5	nsv508458	chr7:65724222-65842639	Enhancers ZNF genes & repeats Weak transcription Strong transcription Flanking Active TSS Genic enhancers Bivalent Enhancer Active TSS Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	3 gene(s)	inside rSNPs	diseases

mRNA abundance (count:18)

SNP	Gene	Cis/trans	Tissue	Source
rs10276077	GTF2IRD1P1	cis	Thyroid	GTEx
rs10276077	RP4-756H11.3	cis	Artery Tibial	GTEx
rs10276077	LINC00174	cis	Thyroid	GTEx
rs10276077	RNU6-96P	cis	Thyroid	GTEx
rs10276077	RP4-756H11.3	cis	Thyroid	GTEx
rs10276077	GS1-124K5.4	cis	Skin Sun Exposed Lower leg	GTEx
rs10276077	RP4-756H11.3	cis	lung	GTEx
rs10276077	RP4-756H11.3	cis	Skin Sun Exposed Lower leg	GTEx
rs10276077	RP4-756H11.3	cis	Heart Left Ventricle	GTEx
rs10276077	GS1-124K5.2	cis	Whole Blood	GTEx
rs10276077	RP4-756H11.3	cis	Esophagus Mucosa	GTEx
rs10276077	GS1-124K5.4	cis	Stomach	GTEx
rs10276077	RP4-756H11.3	cis	Nerve Tibial	GTEx
rs10276077	RP4-756H11.3	cis	Esophagus Muscularis	GTEx
rs10276077	ASL	Cis_1M	lymphoblastoid	RTeQTL
rs10276077	GS1-124K5.11	cis	Thyroid	GTEx
rs10276077	RP4-756H11.3	cis	Adipose Subcutaneous	GTEx
rs10276077	RP4-756H11.3	cis	Muscle Skeletal	GTEx

Chromatin state (count:31 , 50 per page) page: 1

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr7:65701600-65729200	Weak transcription	Duodenum Smooth Muscle	Duodenum
2	chr7:65704200-65729200	Weak transcription	Aorta	Aorta
3	chr7:65704200-65731200	Weak transcription	hESC Derived CD56+ Ectoderm Cultured Cells	ES cell derived
4	chr7:65704400-65746800	Weak transcription	Pancreas	Pancrea
5	chr7:65705800-65729200	Weak transcription	H1 BMP4 Derived Trophoblast Cultured Cells	ES cell derived
6	chr7:65712800-65729200	Weak transcription	Fetal Adrenal Gland	Adrenal Gland
7	chr7:65719800-65730400	Weak transcription	Right Ventricle	heart
8	chr7:65721400-65728800	Weak transcription	NHLF	lung
9	chr7:65723800-65728800	Weak transcription	Foreskin Keratinocyte Primary Cells skin03	Skin
10	chr7:65723800-65728800	Weak transcription	Liver	Liver
11	chr7:65723800-65730200	Weak transcription	Muscle Satellite Cultured Cells	--
12	chr7:65724000-65730400	Weak transcription	iPS-15b Cell Line	embryonic stem cell
13	chr7:65724200-65728600	Weak transcription	Osteobl	bone
14	chr7:65724200-65730000	Weak transcription	ES-UCSF4 Cell Line	embryonic stem cell
15	chr7:65724600-65729800	Weak transcription	Bone Marrow Derived Cultured Mesenchymal Stem Cells	Bone marrow
16	chr7:65725000-65729200	Weak transcription	Breast Myoepithelial Primary Cells	Breast
17	chr7:65726000-65728800	Weak transcription	NHDF-Ad	bronchial
18	chr7:65727200-65729200	Weak transcription	Foreskin Fibroblast Primary Cells skin01	Skin
19	chr7:65727600-65729200	Weak transcription	Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	ES cell derived
20	chr7:65727600-65731800	Weak transcription	Ovary	ovary
21	chr7:65727800-65728800	Weak transcription	IMR90 fetal lung fibroblasts Cell Line	lung
22	chr7:65727800-65729000	Weak transcription	H1 Derived Mesenchymal Stem Cells	ES cell derived
23	chr7:65727800-65729400	Genic enhancers	Mesenchymal Stem Cell Derived Chondrocyte Cultured Cells	embryonic stem cell
24	chr7:65728200-65729400	Strong transcription	Foreskin Keratinocyte Primary Cells skin02	Skin
25	chr7:65728200-65732000	ZNF genes & repeats	hESC Derived CD184+ Endoderm Cultured Cells	ES cell derived
26	chr7:65728400-65729000	Enhancers	HUVEC	blood vessel
27	chr7:65728400-65729200	ZNF genes & repeats	NHEK	skin
28	chr7:65728400-65729400	Strong transcription	Breast variant Human Mammary Epithelial Cells (vHMEC)	Breast
29	chr7:65728400-65729400	Strong transcription	Fetal Lung	lung
30	chr7:65728400-65729800	Strong transcription	Foreskin Fibroblast Primary Cells skin02	Skin
31	chr7:65728400-65731600	ZNF genes & repeats	Adipose Derived Mesenchymal Stem Cell Cultured Cells	ES cell derived

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