Variant report

Variant	rs4503528
Chromosome Location	chr11:8664454-8664455
allele	A/G
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Distal block	Cell Line	Cell type	Cell Stage
1	chr11:8662787..8665429-chr11:8709016..8712010,2	K562	blood:

Variant related genes	Relation type
ENSG00000166441	Chromatin interaction

Extended variants
information (count: 49 )
Associated
traits (count: 3 )

rSNPs within LD-proxies of this variant (count:47)

rs_ID	r²[population]
rs10128597	0.88[AMR][1000 genomes];0.94[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs10769931	0.81[AMR][1000 genomes];0.96[ASN][1000 genomes]
rs10769932	0.91[ASN][1000 genomes]
rs10769936	0.82[AFR][1000 genomes];0.97[AMR][1000 genomes];0.98[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs10769938	0.86[AMR][1000 genomes];0.99[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs10769939	0.92[AFR][1000 genomes];0.85[AMR][1000 genomes];0.98[ASN][1000 genomes]
rs10840099	0.83[AMR][1000 genomes];0.96[ASN][1000 genomes]
rs10840100	0.83[AMR][1000 genomes];1.00[ASN][1000 genomes]
rs10840102	0.90[AMR][1000 genomes];0.98[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs10840104	0.89[AMR][1000 genomes];0.96[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs11042016	0.96[ASN][1000 genomes]
rs11042017	0.83[AMR][1000 genomes];0.99[ASN][1000 genomes]
rs11042018	0.83[AMR][1000 genomes];0.99[ASN][1000 genomes]
rs11042023	0.83[AMR][1000 genomes];1.00[ASN][1000 genomes]
rs11042025	0.93[AFR][1000 genomes];0.99[AMR][1000 genomes];0.99[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs11042029	0.96[AMR][1000 genomes];0.96[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs11042030	0.89[AMR][1000 genomes];0.96[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs12271470	0.94[AMR][1000 genomes];0.96[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs12575252	0.83[AMR][1000 genomes];0.98[ASN][1000 genomes]
rs12803166	0.83[AMR][1000 genomes];0.97[ASN][1000 genomes]
rs1502317	0.96[AMR][1000 genomes];0.97[EUR][1000 genomes];0.92[ASN][1000 genomes]
rs2316901	0.83[AMR][1000 genomes];0.97[ASN][1000 genomes]
rs34867877	0.81[AMR][1000 genomes];0.94[ASN][1000 genomes]
rs35319120	0.89[AMR][1000 genomes];0.99[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs36092927	0.83[AMR][1000 genomes];0.96[ASN][1000 genomes]
rs4256980	0.83[AMR][1000 genomes];0.99[ASN][1000 genomes]
rs4272783	0.95[AFR][1000 genomes];0.99[AMR][1000 genomes];0.96[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs4291677	0.91[AFR][1000 genomes];0.99[AMR][1000 genomes];0.96[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs4495896	0.89[AFR][1000 genomes];0.99[AMR][1000 genomes];0.94[EUR][1000 genomes];0.91[ASN][1000 genomes]
rs4929923	0.81[AMR][1000 genomes];0.96[ASN][1000 genomes]
rs4929924	0.96[ASN][1000 genomes]
rs4929925	0.83[AMR][1000 genomes];0.99[ASN][1000 genomes]
rs4929926	0.83[AMR][1000 genomes];1.00[ASN][1000 genomes]
rs4929927	0.83[AMR][1000 genomes];1.00[ASN][1000 genomes]
rs4929928	0.83[AMR][1000 genomes];0.98[ASN][1000 genomes]
rs4929947	0.96[ASN][1000 genomes]
rs4929948	0.83[AMR][1000 genomes];0.99[ASN][1000 genomes]
rs6486253	0.83[AMR][1000 genomes];0.96[ASN][1000 genomes]
rs7110529	0.89[AMR][1000 genomes];0.94[EUR][1000 genomes];0.92[ASN][1000 genomes]
rs7113874	0.83[AMR][1000 genomes];0.98[ASN][1000 genomes]
rs7118611	0.89[AMR][1000 genomes];0.95[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs7126235	0.83[AMR][1000 genomes];0.98[ASN][1000 genomes]
rs7939673	0.96[AMR][1000 genomes];0.99[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs7941510	0.90[AMR][1000 genomes];0.98[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs7950166	0.96[ASN][1000 genomes]
rs7950528	0.94[ASN][1000 genomes]
rs885114	0.92[AFR][1000 genomes];0.99[AMR][1000 genomes];0.98[EUR][1000 genomes];0.98[ASN][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:2 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	esv2751035	chr11:8431654-8685451	Strong transcription Weak transcription Enhancers ZNF genes & repeats Genic enhancers Flanking Active TSS Bivalent/Poised TSS Active TSS Bivalent Enhancer Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA	8 gene(s)	inside rSNPs	diseases
2	nsv896983	chr11:8526643-8682465	ZNF genes & repeats Strong transcription Weak transcription Bivalent Enhancer Flanking Active TSS Enhancers Active TSS Flanking Bivalent TSS/Enh Bivalent/Poised TSS Genic enhancers	TF binding region CpG island Chromatin interactive region lncRNA	8 gene(s)	inside rSNPs	diseases

mRNA abundance (count:3)

SNP	Gene	Cis/trans	Tissue	Source
rs4503528	TRIM66	cis	Skin Sun Exposed Lower leg	GTEx
rs4503528	TRIM66	cis	Whole Blood	GTEx
rs4503528	TRIM66	cis	Nerve Tibial	GTEx

Chromatin state (count:122 , 50 per page) page: 1 2 3

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr11:8637000-8703200	Weak transcription	Small Intestine	intestine
2	chr11:8641800-8666200	Weak transcription	Primary T helper memory cells from peripheral blood 2	blood
3	chr11:8644800-8667000	Weak transcription	Primary T helper memory cells from peripheral blood 1	blood
4	chr11:8646200-8671000	Weak transcription	HUVEC	blood vessel
5	chr11:8646400-8666400	Weak transcription	HSMM	muscle
6	chr11:8649600-8665400	Weak transcription	Primary T killer memory cells from peripheral blood	blood
7	chr11:8650800-8676200	Strong transcription	Monocytes-CD14+_RO01746	blood
8	chr11:8652200-8675000	Strong transcription	Primary monocytes fromperipheralblood	blood
9	chr11:8653400-8667000	Weak transcription	Rectal Smooth Muscle	rectum
10	chr11:8654000-8673800	Strong transcription	Primary B cells from peripheral blood	blood
11	chr11:8654200-8673800	Strong transcription	Primary T helper cells fromperipheralblood	blood
12	chr11:8654200-8675600	Strong transcription	Stomach Smooth Muscle	stomach
13	chr11:8654400-8672400	Strong transcription	Brain Anterior Caudate	brain
14	chr11:8655000-8670200	Strong transcription	Adipose Derived Mesenchymal Stem Cell Cultured Cells	ES cell derived
15	chr11:8655000-8676400	Strong transcription	Primary T cells from cord blood	blood
16	chr11:8655200-8664800	Strong transcription	Lung	lung
17	chr11:8655200-8665000	Strong transcription	Brain Inferior Temporal Lobe	brain
18	chr11:8655200-8672600	Strong transcription	Primary mononuclear cells fromperipheralblood	Blood
19	chr11:8655400-8666600	Weak transcription	Fetal Thymus	thymus
20	chr11:8655400-8673400	Strong transcription	Dnd41	blood
21	chr11:8655600-8670600	Strong transcription	Adipose Nuclei	Adipose
22	chr11:8656000-8670600	Strong transcription	Fetal Muscle Leg	muscle
23	chr11:8656000-8672600	Strong transcription	Skeletal Muscle Female	skeletal muscle
24	chr11:8656000-8672800	Strong transcription	Placenta	Placenta
25	chr11:8656600-8671600	Strong transcription	Brain Cingulate Gyrus	brain
26	chr11:8656800-8666800	Weak transcription	HMEC	breast
27	chr11:8657200-8673800	Strong transcription	Primary neutrophils fromperipheralblood	blood
28	chr11:8657400-8672600	Strong transcription	Primary T regulatory cells fromperipheralblood	blood
29	chr11:8658000-8666400	Weak transcription	H9 Derived Neuron Cultured Cells	ES cell derived
30	chr11:8658000-8675200	Strong transcription	Primary Natural Killer cells fromperipheralblood	blood
31	chr11:8658200-8672400	Strong transcription	Primary hematopoietic stem cells short term culture	blood
32	chr11:8658200-8673800	Strong transcription	Primary T helper naive cells fromperipheralblood	blood
33	chr11:8658400-8671200	Strong transcription	Primary T helper cells PMA-I stimulated	--
34	chr11:8658400-8671600	Strong transcription	Primary hematopoietic stem cells G-CSF-mobilized Male	--
35	chr11:8658600-8673000	Strong transcription	Fetal Adrenal Gland	Adrenal Gland
36	chr11:8658600-8674200	Strong transcription	Primary T cells fromperipheralblood	blood
37	chr11:8658600-8675000	Strong transcription	Liver	Liver
38	chr11:8659200-8670400	Strong transcription	Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	ES cell derived
39	chr11:8659200-8673600	Weak transcription	Colon Smooth Muscle	Colon
40	chr11:8659400-8669000	Weak transcription	Primary T helper naive cells from peripheral blood	blood
41	chr11:8660000-8665400	Weak transcription	Primary hematopoietic stem cells	blood
42	chr11:8660000-8665400	Weak transcription	Primary T killer naive cells fromperipheralblood	blood
43	chr11:8660000-8666600	Weak transcription	NHLF	lung
44	chr11:8660000-8667200	Weak transcription	H9 Derived Neuronal Progenitor Cultured Cells	ES cell derived
45	chr11:8660000-8667400	Weak transcription	HSMMtube	muscle
46	chr11:8660000-8669200	Weak transcription	H1 BMP4 Derived Trophoblast Cultured Cells	ES cell derived
47	chr11:8660200-8666600	Weak transcription	Osteobl	bone
48	chr11:8660200-8671000	Weak transcription	NHDF-Ad	bronchial
49	chr11:8660400-8667200	Weak transcription	NH-A	brain
50	chr11:8660400-8669200	Weak transcription	Colonic Mucosa	Colon

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