Variant report

Variant	rs61874731
Chromosome Location	chr10:93638620-93638621
allele	C/T
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Distal block	Cell Line	Cell type
1	chr10:93638059..93641672-chr10:93681049..93683589,4	MCF-7	breast:
2	chr10:93638107..93642679-chr10:93666717..93670620,8	MCF-7	breast:
3	chr10:93620389..93623626-chr10:93637886..93641413,3	MCF-7	breast:

Variant related genes	Relation type
ENSG00000095564	Chromatin interaction
ENSG00000272817	Chromatin interaction
ENSG00000174721	Chromatin interaction

Extended variants
information (count: 40 )
Associated
traits (count: 7 )

rSNPs within LD-proxies of this variant (count:37)

rs_ID	r²[population]
rs10509636	0.81[AFR][1000 genomes];0.92[AMR][1000 genomes];0.93[EUR][1000 genomes];0.88[ASN][1000 genomes]
rs10786019	0.81[AFR][1000 genomes];0.95[AMR][1000 genomes];0.93[EUR][1000 genomes];0.91[ASN][1000 genomes]
rs10881960	0.82[EUR][1000 genomes]
rs10881969	0.87[AMR][1000 genomes];0.86[EUR][1000 genomes]
rs10881971	0.87[AMR][1000 genomes];0.86[EUR][1000 genomes]
rs10881975	0.88[AMR][1000 genomes];0.86[EUR][1000 genomes]
rs10881980	0.81[AFR][1000 genomes];0.93[AMR][1000 genomes];0.93[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs10881981	0.81[AFR][1000 genomes];0.94[AMR][1000 genomes];0.93[EUR][1000 genomes];0.91[ASN][1000 genomes]
rs10881985	0.98[AMR][1000 genomes];0.94[EUR][1000 genomes];0.91[ASN][1000 genomes]
rs10881989	0.88[AMR][1000 genomes];0.96[ASN][1000 genomes]
rs11186668	0.80[EUR][1000 genomes]
rs11186697	0.88[AMR][1000 genomes];0.85[EUR][1000 genomes]
rs12220444	0.81[AFR][1000 genomes];0.93[AMR][1000 genomes];0.93[EUR][1000 genomes];0.91[ASN][1000 genomes]
rs12221087	0.88[AMR][1000 genomes];0.85[EUR][1000 genomes]
rs12412538	0.81[AFR][1000 genomes];0.97[AMR][1000 genomes];0.94[EUR][1000 genomes];0.92[ASN][1000 genomes]
rs12413090	0.81[AFR][1000 genomes];0.97[AMR][1000 genomes];0.93[EUR][1000 genomes];0.91[ASN][1000 genomes]
rs12413256	0.81[AFR][1000 genomes];0.93[AMR][1000 genomes];0.93[EUR][1000 genomes];0.91[ASN][1000 genomes]
rs12782935	0.87[AMR][1000 genomes];0.86[EUR][1000 genomes]
rs1417254	0.91[AFR][1000 genomes];0.94[AMR][1000 genomes];0.94[EUR][1000 genomes];0.91[ASN][1000 genomes]
rs1539040	0.88[AMR][1000 genomes];0.85[EUR][1000 genomes]
rs2066275	0.87[AMR][1000 genomes];0.86[EUR][1000 genomes]
rs2297960	0.81[AFR][1000 genomes];0.94[AMR][1000 genomes];0.93[EUR][1000 genomes];0.91[ASN][1000 genomes]
rs2901505	0.81[AMR][1000 genomes];0.82[EUR][1000 genomes]
rs3758499	0.81[AFR][1000 genomes];0.95[AMR][1000 genomes];0.93[EUR][1000 genomes];0.91[ASN][1000 genomes]
rs4390259	0.99[AMR][1000 genomes];0.94[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs4603212	0.84[AMR][1000 genomes];0.97[ASN][1000 genomes]
rs61874730	0.95[AMR][1000 genomes];0.96[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs7082350	0.81[AFR][1000 genomes];0.98[AMR][1000 genomes];0.94[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs7087365	0.81[AFR][1000 genomes];0.97[AMR][1000 genomes];0.94[EUR][1000 genomes];0.92[ASN][1000 genomes]
rs7903827	0.89[AMR][1000 genomes];0.86[EUR][1000 genomes];0.96[ASN][1000 genomes]
rs7906805	0.81[AFR][1000 genomes];0.93[AMR][1000 genomes];0.93[EUR][1000 genomes];0.91[ASN][1000 genomes]
rs7912927	0.81[AFR][1000 genomes];0.94[AMR][1000 genomes];0.93[EUR][1000 genomes];0.91[ASN][1000 genomes]
rs7913826	0.81[AFR][1000 genomes];0.92[AMR][1000 genomes];0.93[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs7913999	0.81[AFR][1000 genomes];0.97[AMR][1000 genomes];0.94[EUR][1000 genomes];0.91[ASN][1000 genomes]
rs7917710	0.94[AMR][1000 genomes];0.88[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs7919141	0.84[AFR][1000 genomes];1.00[AMR][1000 genomes];0.96[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs7921354	0.93[AMR][1000 genomes];0.93[EUR][1000 genomes];0.91[ASN][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:3 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv7491	chr10:93626192-93671694	Enhancers Weak transcription Active TSS Flanking Active TSS Bivalent Enhancer Strong transcription Transcr. at gene 5' and 3' Bivalent/Poised TSS Flanking Bivalent TSS/Enh Genic enhancers ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA	7 gene(s)	inside rSNPs	diseases
2	esv1819110	chr10:93634155-93643195	Weak transcription Enhancers Flanking Active TSS Bivalent Enhancer ZNF genes & repeats Active TSS	Chromatin interactive region	3 gene(s)	inside rSNPs	diseases
3	esv1842657	chr10:93634155-93668663	Flanking Active TSS Enhancers Weak transcription Active TSS ZNF genes & repeats Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh Genic enhancers Bivalent Enhancer Bivalent/Poised TSS Strong transcription	TF binding region CpG island Chromatin interactive region lncRNA	7 gene(s)	inside rSNPs	diseases

mRNA abundance (count:7)

SNP	Gene	Cis/trans	Tissue	Source
rs61874731	TNKS2	cis	Skin Sun Exposed Lower leg	GTEx
rs61874731	TNKS2	cis	Thyroid	GTEx
rs61874731	TNKS2	cis	Adipose Subcutaneous	GTEx
rs61874731	TNKS2	cis	temporal cortex	BrainEAC
rs61874731	TNKS2	cis	Nerve Tibial	GTEx
rs61874731	TNKS2	cis	Esophagus Muscularis	GTEx
rs61874731	TNKS2-AS1	cis	Heart Left Ventricle	GTEx

Chromatin state (count:23 , 50 per page) page: 1

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr10:93608800-93639200	Weak transcription	H1 Derived Mesenchymal Stem Cells	ES cell derived
2	chr10:93608800-93643400	Weak transcription	iPS DF 6.9 Cell Line	embryonic stem cell
3	chr10:93618400-93639400	Weak transcription	Brain Cingulate Gyrus	brain
4	chr10:93622600-93639000	Weak transcription	Brain Germinal Matrix	brain
5	chr10:93622800-93639200	Weak transcription	Brain Angular Gyrus	brain
6	chr10:93624200-93639200	Weak transcription	Foreskin Keratinocyte Primary Cells skin03	Skin
7	chr10:93625800-93639000	Weak transcription	Fetal Brain Female	brain
8	chr10:93626200-93639600	Weak transcription	Rectal Mucosa Donor 31	rectum
9	chr10:93626200-93643000	Weak transcription	HSMMtube	muscle
10	chr10:93627600-93639000	Weak transcription	HUES64 Cell Line	embryonic stem cell
11	chr10:93627600-93639600	Weak transcription	Breast variant Human Mammary Epithelial Cells (vHMEC)	Breast
12	chr10:93627800-93639000	Weak transcription	ES-I3 Cell Line	embryonic stem cell
13	chr10:93629600-93638800	Weak transcription	hESC Derived CD184+ Endoderm Cultured Cells	ES cell derived
14	chr10:93629600-93639000	Weak transcription	iPS-18 Cell Line	embryonic stem cell
15	chr10:93629600-93639200	Weak transcription	H9 Cell Line	embryonic stem cell
16	chr10:93632800-93639200	Weak transcription	Placenta	Placenta
17	chr10:93634800-93639000	Weak transcription	iPS-20b Cell Line	embryonic stem cell
18	chr10:93634800-93639000	Weak transcription	Cortex derived primary cultured neurospheres	brain
19	chr10:93634800-93639000	Weak transcription	Ganglion Eminence derived primary cultured neurospheres	brain
20	chr10:93635000-93643200	Weak transcription	Right Atrium	heart
21	chr10:93635200-93639200	Weak transcription	H1 Derived Neuronal Progenitor Cultured Cells	ES cell derived
22	chr10:93637400-93639200	Weak transcription	Foreskin Melanocyte Primary Cells skin03	Skin
23	chr10:93637800-93639000	Weak transcription	H1 BMP4 Derived Mesendoderm Cultured Cells	ES cell derived

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