Variant report

Variant	rs10840087
Chromosome Location	chr11:8616255-8616256
allele	A/G
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Transcrition factor	Chromosome Location	Cell Line	Cell type	Cell Stage	Matched TF binding sites
1	EP300	chr11:8616230-8616287	HepG2	liver:	n/a	n/a
2	SIN3A	chr11:8615158-8616360	H1-hESC	embryonic stem cell:	n/a	chr11:8615843-8615852 chr11:8615845-8615854
3	CHD2	chr11:8615616-8616291	GM12878	blood:	n/a	n/a
4	POLR2A	chr11:8615501-8616473	GM12878	blood:	n/a	n/a
5	MAX	chr11:8615486-8616261	ECC-1	luminal epithelium:	n/a	chr11:8615541-8615550 chr11:8615746-8615756 chr11:8615929-8615948 chr11:8615934-8615943 chr11:8615844-8615853 chr11:8615843-8615854 chr11:8615537-8615546 chr11:8615842-8615851 chr11:8615936-8615943
6	POLR2A	chr11:8615425-8616260	U87	brain:	n/a	n/a
7	USF2	chr11:8615655-8616302	GM12878	blood:	n/a	chr11:8615843-8615854
8	EP300	chr11:8615575-8616409	GM12878	blood:	n/a	chr11:8615631-8615640
9	POLR2A	chr11:8615661-8616343	GM12892	blood:	n/a	n/a
10	POLR2A	chr11:8615553-8616349	HepG2	liver:	n/a	n/a
11	PML	chr11:8615301-8616314	GM12878	blood:	n/a	n/a
12	E2F6	chr11:8615376-8616308	H1-hESC	embryonic stem cell:	n/a	chr11:8615774-8615784
13	POLR2A	chr11:8615283-8616659	H1-hESC	embryonic stem cell:	n/a	n/a
14	STAT3	chr11:8615858-8616359	GM12878	blood:	n/a	n/a
15	POLR2A	chr11:8615494-8616298	GM18526	blood:	n/a	n/a
16	POLR2A	chr11:8615413-8616331	H1-hESC	embryonic stem cell:	n/a	n/a
17	POU2F2	chr11:8615488-8616457	GM12878	blood:	n/a	chr11:8616111-8616123
18	MAX	chr11:8615368-8616340	HCT-116	colon:	n/a	chr11:8615541-8615550 chr11:8615746-8615756 chr11:8615929-8615948 chr11:8615934-8615943 chr11:8615844-8615853 chr11:8615843-8615854 chr11:8615537-8615546 chr11:8615842-8615851 chr11:8615936-8615943
19	MXI1	chr11:8615370-8616397	GM12878	blood:	n/a	chr11:8615933-8615942 chr11:8615537-8615552 chr11:8615535-8615550 chr11:8615845-8615854
20	POLR2A	chr11:8615397-8616268	GM12892	blood:	n/a	n/a
21	MAX	chr11:8615499-8616363	A549	lung:	n/a	chr11:8615541-8615550 chr11:8615746-8615756 chr11:8615929-8615948 chr11:8615934-8615943 chr11:8615844-8615853 chr11:8615843-8615854 chr11:8615537-8615546 chr11:8615842-8615851 chr11:8615936-8615943
22	POLR2A	chr11:8615612-8616344	GM12892	blood:	n/a	n/a
23	POLR2A	chr11:8615530-8616458	GM12891	blood:	n/a	n/a
24	USF1	chr11:8615388-8616262	HCT-116	colon:	n/a	chr11:8615843-8615854
25	CUX1	chr11:8615896-8616259	GM12878	blood:	n/a	n/a
26	POLR2A	chr11:8615698-8616285	GM12878	blood:	n/a	n/a
27	MAX	chr11:8615621-8616274	A549	lung:	n/a	chr11:8615746-8615756 chr11:8615929-8615948 chr11:8615934-8615943 chr11:8615844-8615853 chr11:8615843-8615854 chr11:8615842-8615851 chr11:8615936-8615943
28	MTA3	chr11:8615651-8616593	GM12878	blood:	n/a	n/a
29	POLR2A	chr11:8615543-8616270	HCT-116	colon:	n/a	n/a

Variant related genes	Relation type
STK33	TF binding region

Extended variants
information (count: 97 )
Associated
traits (count: 1 )

rSNPs within LD-proxies of this variant (count:95)

rs_ID	r²[population]
rs10160430	0.91[AFR][1000 genomes];0.99[AMR][1000 genomes];0.95[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs10160805	0.91[AFR][1000 genomes];0.99[AMR][1000 genomes];0.95[EUR][1000 genomes];0.88[ASN][1000 genomes]
rs10743072	0.88[EUR][1000 genomes]
rs10743074	0.86[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs10743080	0.83[AMR][1000 genomes];0.82[ASN][1000 genomes]
rs10743081	0.96[AMR][1000 genomes];0.89[EUR][1000 genomes];0.81[ASN][1000 genomes]
rs10743082	0.82[ASN][1000 genomes]
rs10769907	0.85[EUR][1000 genomes]
rs10769908	0.88[EUR][1000 genomes]
rs10769910	0.88[EUR][1000 genomes]
rs10769915	0.90[AFR][1000 genomes];0.99[AMR][1000 genomes];0.95[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs10769916	0.91[AFR][1000 genomes];0.99[AMR][1000 genomes];0.95[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs10769918	0.91[AMR][1000 genomes];0.93[EUR][1000 genomes]
rs10769921	0.98[AMR][1000 genomes];0.94[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs10769922	0.97[AMR][1000 genomes];0.94[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs10769923	0.84[AMR][1000 genomes];0.82[ASN][1000 genomes]
rs10769924	0.95[AFR][1000 genomes];1.00[AMR][1000 genomes];0.97[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs10769925	0.98[AMR][1000 genomes];0.94[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs10769926	0.98[AMR][1000 genomes];0.94[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs10769927	0.92[AMR][1000 genomes];0.80[EUR][1000 genomes]
rs10769929	0.94[ASN][1000 genomes]
rs10840047	0.84[EUR][1000 genomes]
rs10840051	0.87[EUR][1000 genomes]
rs10840055	0.88[EUR][1000 genomes]
rs10840056	0.88[EUR][1000 genomes]
rs10840058	0.88[EUR][1000 genomes]
rs10840060	0.87[EUR][1000 genomes]
rs10840065	0.89[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs10840072	0.85[AMR][1000 genomes];0.90[EUR][1000 genomes];0.81[ASN][1000 genomes]
rs10840077	0.91[AFR][1000 genomes];0.99[AMR][1000 genomes];0.95[EUR][1000 genomes];0.88[ASN][1000 genomes]
rs10840080	0.90[AFR][1000 genomes];0.98[AMR][1000 genomes];0.95[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs10840083	0.95[AMR][1000 genomes];0.93[EUR][1000 genomes]
rs10840084	0.92[AFR][1000 genomes];1.00[AMR][1000 genomes];0.96[EUR][1000 genomes];0.92[ASN][1000 genomes]
rs10840085	0.95[AMR][1000 genomes];0.93[EUR][1000 genomes]
rs10840089	0.83[AMR][1000 genomes];0.82[ASN][1000 genomes]
rs10840091	0.96[AMR][1000 genomes];0.90[EUR][1000 genomes]
rs11041924	0.84[EUR][1000 genomes]
rs11041962	0.87[AMR][1000 genomes];0.91[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs11041974	0.82[AFR][1000 genomes];0.92[AMR][1000 genomes];0.94[EUR][1000 genomes];0.85[ASN][1000 genomes]
rs11041983	0.86[AFR][1000 genomes];0.96[AMR][1000 genomes];0.95[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs11041985	0.87[AFR][1000 genomes];0.97[AMR][1000 genomes];0.95[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs11041986	0.89[ASN][1000 genomes]
rs11041990	0.91[AMR][1000 genomes];0.92[EUR][1000 genomes]
rs11041993	0.89[AMR][1000 genomes];0.92[EUR][1000 genomes]
rs11041994	0.91[AMR][1000 genomes];0.92[EUR][1000 genomes]
rs11041995	0.94[AMR][1000 genomes];0.92[EUR][1000 genomes]
rs11041997	0.94[AMR][1000 genomes];0.91[EUR][1000 genomes]
rs11041999	0.88[AFR][1000 genomes];0.98[AMR][1000 genomes];0.95[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs11042002	1.00[AFR][1000 genomes];1.00[AMR][1000 genomes];0.99[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs11493772	0.87[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs12277932	0.96[AMR][1000 genomes];0.86[EUR][1000 genomes]
rs12576736	0.86[EUR][1000 genomes]
rs1374262	0.85[EUR][1000 genomes]
rs1446462	0.89[AMR][1000 genomes];0.93[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs1446463	0.89[AMR][1000 genomes];0.93[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs1900272	0.84[ASN][1000 genomes]
rs1900273	0.88[EUR][1000 genomes]
rs2015629	0.82[AMR][1000 genomes];0.87[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs2044463	0.86[EUR][1000 genomes]
rs2289921	0.88[EUR][1000 genomes]
rs2871753	0.88[EUR][1000 genomes]
rs3969875	0.85[EUR][1000 genomes]
rs4244804	0.95[AMR][1000 genomes];0.96[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs4418812	0.91[AFR][1000 genomes];1.00[AMR][1000 genomes];0.97[EUR][1000 genomes];0.92[ASN][1000 genomes]
rs4475924	0.98[AMR][1000 genomes];0.96[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs4520598	0.81[ASN][1000 genomes]
rs4612809	0.98[AMR][1000 genomes];0.96[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs4620720	0.95[AMR][1000 genomes];0.96[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs4929941	0.84[AMR][1000 genomes];0.82[ASN][1000 genomes]
rs4929942	0.91[AFR][1000 genomes];1.00[AMR][1000 genomes];0.96[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs4929943	0.98[AMR][1000 genomes];0.93[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs4929944	0.97[AMR][1000 genomes];0.92[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs4929945	0.97[AMR][1000 genomes];0.92[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs4929949	0.92[AFR][1000 genomes];1.00[AMR][1000 genomes];0.96[EUR][1000 genomes];0.88[ASN][1000 genomes]
rs6484485	0.98[AMR][1000 genomes];0.94[EUR][1000 genomes];0.82[ASN][1000 genomes]
rs6578968	0.88[EUR][1000 genomes]
rs6578969	0.88[EUR][1000 genomes]
rs7101471	0.86[EUR][1000 genomes]
rs7112153	0.84[EUR][1000 genomes]
rs7120065	0.86[EUR][1000 genomes]
rs7127684	0.86[EUR][1000 genomes]
rs7924753	0.88[EUR][1000 genomes]
rs7934396	0.86[AFR][1000 genomes];0.99[AMR][1000 genomes];0.96[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs7935708	0.88[EUR][1000 genomes]
rs7947670	0.90[EUR][1000 genomes];0.81[ASN][1000 genomes]
rs7949017	0.89[EUR][1000 genomes]
rs7950870	0.83[AMR][1000 genomes];0.80[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs9300090	0.87[AMR][1000 genomes];0.92[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs9300091	0.87[AFR][1000 genomes];0.97[AMR][1000 genomes];0.95[EUR][1000 genomes];0.83[ASN][1000 genomes]
rs935370	0.84[EUR][1000 genomes]
rs9705083	0.88[AMR][1000 genomes];0.91[EUR][1000 genomes]
rs9705253	0.87[AFR][1000 genomes];0.99[AMR][1000 genomes];0.95[EUR][1000 genomes];0.88[ASN][1000 genomes]
rs9736791	0.92[AMR][1000 genomes];0.94[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs9737312	0.88[AMR][1000 genomes];0.92[EUR][1000 genomes]
rs9737401	0.87[AFR][1000 genomes];0.95[AMR][1000 genomes];0.92[EUR][1000 genomes];0.82[ASN][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:2 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	esv2751035	chr11:8431654-8685451	Strong transcription Weak transcription Enhancers ZNF genes & repeats Genic enhancers Flanking Active TSS Bivalent/Poised TSS Active TSS Bivalent Enhancer Flanking Bivalent TSS/Enh	TF binding region CpG island Chromatin interactive region lncRNA	8 gene(s)	inside rSNPs	diseases
2	nsv896983	chr11:8526643-8682465	ZNF genes & repeats Strong transcription Weak transcription Bivalent Enhancer Flanking Active TSS Enhancers Active TSS Flanking Bivalent TSS/Enh Bivalent/Poised TSS Genic enhancers	TF binding region CpG island Chromatin interactive region lncRNA	8 gene(s)	inside rSNPs	diseases

mRNA abundance (count:1)

SNP	Gene	Cis/trans	Tissue	Source
rs10840087	STK33	cis	Artery Tibial	GTEx

Chromatin state (count:74 , 50 per page) page: 1 2

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr11:8614600-8616400	Active TSS	H9 Derived Neuronal Progenitor Cultured Cells	ES cell derived
2	chr11:8614600-8616400	Active TSS	HUES64 Cell Line	embryonic stem cell
3	chr11:8614600-8616400	Active TSS	iPS-20b Cell Line	embryonic stem cell
4	chr11:8614800-8616400	Flanking Active TSS	Primary hematopoietic stem cells short term culture	blood
5	chr11:8614800-8616400	Bivalent/Poised TSS	Duodenum Smooth Muscle	Duodenum
6	chr11:8614800-8616600	Flanking Active TSS	Primary hematopoietic stem cells G-CSF-mobilized Male	--
7	chr11:8615000-8616400	Active TSS	ES-WA7 Cell Line	embryonic stem cell
8	chr11:8615000-8616400	Active TSS	H9 Cell Line	embryonic stem cell
9	chr11:8615000-8616400	Active TSS	hESC Derived CD56+ Ectoderm Cultured Cells	ES cell derived
10	chr11:8615000-8616400	Active TSS	iPS DF 6.9 Cell Line	embryonic stem cell
11	chr11:8615000-8616400	Flanking Active TSS	Primary hematopoietic stem cells G-CSF-mobilized Female	--
12	chr11:8615000-8616400	Flanking Active TSS	Foreskin Fibroblast Primary Cells skin01	Skin
13	chr11:8615000-8616400	Active TSS	Fetal Intestine Large	intestine
14	chr11:8615000-8616400	Active TSS	Rectal Mucosa Donor 29	rectum
15	chr11:8615000-8616400	Active TSS	Right Atrium	heart
16	chr11:8615000-8616400	Active TSS	Right Ventricle	heart
17	chr11:8615200-8616400	Flanking Active TSS	Primary hematopoietic stem cells	blood
18	chr11:8615200-8616400	Bivalent/Poised TSS	Brain Cingulate Gyrus	brain
19	chr11:8615200-8616400	Active TSS	Brain Substantia Nigra	brain
20	chr11:8615200-8616400	Active TSS	Fetal Brain Female	brain
21	chr11:8615200-8616400	Flanking Bivalent TSS/Enh	HUVEC	blood vessel
22	chr11:8615400-8616400	Bivalent Enhancer	Liver	Liver
23	chr11:8615800-8616400	Flanking Active TSS	Duodenum Mucosa	Duodenum
24	chr11:8615800-8616400	Flanking Active TSS	Rectal Smooth Muscle	rectum
25	chr11:8615800-8616400	Flanking Bivalent TSS/Enh	Skeletal Muscle Male	skeletal muscle
26	chr11:8615800-8616400	Flanking Bivalent TSS/Enh	Skeletal Muscle Female	skeletal muscle
27	chr11:8615800-8616400	Flanking Active TSS	Stomach Smooth Muscle	stomach
28	chr11:8615800-8616400	Flanking Active TSS	HepG2	liver
29	chr11:8615800-8616400	Flanking Active TSS	NH-A	brain
30	chr11:8616000-8616400	Flanking Active TSS	hESC Derived CD184+ Endoderm Cultured Cells	ES cell derived
31	chr11:8616000-8616400	Flanking Active TSS	HUES48 Cell Line	embryonic stem cell
32	chr11:8616000-8616400	Bivalent Enhancer	Primary monocytes fromperipheralblood	blood
33	chr11:8616000-8616400	Bivalent Enhancer	Primary T killer naive cells fromperipheralblood	blood
34	chr11:8616000-8616400	Flanking Bivalent TSS/Enh	Brain Hippocampus Middle	brain
35	chr11:8616000-8616400	Flanking Bivalent TSS/Enh	Brain Inferior Temporal Lobe	brain
36	chr11:8616000-8616400	Flanking Bivalent TSS/Enh	Brain Dorsolateral Prefrontal Cortex	brain
37	chr11:8616000-8616400	Flanking Active TSS	Colon Smooth Muscle	Colon
38	chr11:8616000-8616400	Bivalent Enhancer	Fetal Lung	lung
39	chr11:8616000-8616400	Bivalent Enhancer	Placenta Amnion	Placenta Amnion
40	chr11:8616000-8616400	Bivalent Enhancer	Small Intestine	intestine
41	chr11:8616000-8616400	Flanking Active TSS	A549	lung
42	chr11:8616000-8616400	Flanking Active TSS	Hela-S3	cervix
43	chr11:8616000-8616400	Flanking Bivalent TSS/Enh	HSMMtube	muscle
44	chr11:8616000-8616600	Flanking Active TSS	H1 Cell Line	embryonic stem cell
45	chr11:8616000-8616600	Flanking Active TSS	iPS-18 Cell Line	embryonic stem cell
46	chr11:8616000-8616600	Flanking Active TSS	Cortex derived primary cultured neurospheres	brain
47	chr11:8616000-8616600	Flanking Active TSS	Stomach Mucosa	stomach
48	chr11:8616000-8616600	Flanking Active TSS	GM12878-XiMat	blood
49	chr11:8616000-8616800	Flanking Active TSS	Ganglion Eminence derived primary cultured neurospheres	brain
50	chr11:8616200-8616400	Flanking Active TSS	ES-UCSF4 Cell Line	embryonic stem cell

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