Variant report

Variant	rs4586057
Chromosome Location	chr10:92632899-92632900
allele	G/T
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Transcrition factor	Chromosome Location	Cell Line	Cell type	Cell Stage	Matched TF binding sites
1	MXI1	chr10:92630573-92633017	SK-N-SH	brain:	n/a	n/a

No.	Distal block	Cell Line	Cell type	Cell Stage
1	chr10:92629379..92632289-chr10:92632395..92635365,2	K562	blood:
2	chr10:92631710..92635669-chr10:92637980..92642007,3	K562	blood:

Variant related genes	Relation type
RPP30	TF binding region
ENSG00000148688	Chromatin interaction
ENSG00000222305	Chromatin interaction

Extended variants
information (count: 69 )
Associated
traits (count: 2 )

rSNPs within LD-proxies of this variant (count:68)

rs_ID	r²[population]
rs10881829	0.92[CHB][hapmap];0.89[CHD][hapmap];0.84[JPT][hapmap];0.84[ASN][1000 genomes]
rs10881831	0.89[ASN][1000 genomes]
rs10881833	0.91[CHB][hapmap];0.81[JPT][hapmap];0.90[ASN][1000 genomes]
rs10881834	0.90[ASN][1000 genomes]
rs10881835	0.92[CHB][hapmap];0.92[JPT][hapmap];0.90[ASN][1000 genomes]
rs10881841	0.89[CEU][hapmap];1.00[CHB][hapmap];1.00[JPT][hapmap];0.97[ASN][1000 genomes]
rs10881843	0.94[AFR][1000 genomes];0.96[AMR][1000 genomes];0.98[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs10881845	0.89[CEU][hapmap];1.00[CHB][hapmap];1.00[JPT][hapmap];0.97[ASN][1000 genomes]
rs10881846	0.94[ASW][hapmap];1.00[CEU][hapmap];0.92[CHB][hapmap];0.89[CHD][hapmap];1.00[GIH][hapmap];1.00[JPT][hapmap];1.00[LWK][hapmap];1.00[MEX][hapmap];1.00[MKK][hapmap];1.00[TSI][hapmap];1.00[YRI][hapmap];0.94[AFR][1000 genomes];0.96[AMR][1000 genomes];0.98[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs10881848	0.85[CHB][hapmap];0.91[JPT][hapmap];0.80[AFR][1000 genomes];0.92[AMR][1000 genomes];0.98[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs10881850	1.00[CEU][hapmap];1.00[CHB][hapmap];1.00[CHD][hapmap];1.00[GIH][hapmap];1.00[JPT][hapmap];1.00[MEX][hapmap];1.00[TSI][hapmap];0.96[AMR][1000 genomes];0.98[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs11186282	0.81[ASN][1000 genomes]
rs11186292	0.84[ASN][1000 genomes]
rs11186298	0.92[CHB][hapmap];0.93[CHD][hapmap];0.84[JPT][hapmap];0.86[ASN][1000 genomes]
rs11186299	0.92[CHB][hapmap];0.90[JPT][hapmap];0.86[ASN][1000 genomes]
rs11186305	0.89[ASN][1000 genomes]
rs11186306	0.92[CHB][hapmap];0.90[ASN][1000 genomes]
rs11186315	0.88[ASN][1000 genomes]
rs11186323	0.90[ASN][1000 genomes]
rs11186333	0.92[CHB][hapmap];0.96[CHD][hapmap];0.92[JPT][hapmap];0.94[ASN][1000 genomes]
rs11186336	0.89[AFR][1000 genomes];0.95[AMR][1000 genomes];0.93[EUR][1000 genomes];0.99[ASN][1000 genomes]
rs11186338	0.89[CEU][hapmap];1.00[CHB][hapmap];1.00[CHD][hapmap];1.00[JPT][hapmap];0.97[ASN][1000 genomes]
rs11186339	0.86[ASN][1000 genomes]
rs11186343	1.00[CHB][hapmap];1.00[CHD][hapmap];1.00[JPT][hapmap];0.97[ASN][1000 genomes]
rs11186344	0.97[ASN][1000 genomes]
rs11186346	1.00[CHB][hapmap];1.00[JPT][hapmap];0.97[ASN][1000 genomes]
rs11186352	0.89[CEU][hapmap];1.00[CHB][hapmap];1.00[JPT][hapmap];0.97[ASN][1000 genomes]
rs11186358	0.96[AMR][1000 genomes];0.98[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs11186359	1.00[CEU][hapmap];1.00[CHB][hapmap];1.00[CHD][hapmap];1.00[GIH][hapmap];1.00[JPT][hapmap];1.00[MEX][hapmap];1.00[TSI][hapmap];0.96[AMR][1000 genomes];0.98[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs11186360	0.89[CEU][hapmap];1.00[CHB][hapmap];1.00[CHD][hapmap];1.00[JPT][hapmap];0.94[ASN][1000 genomes]
rs11186361	0.96[AMR][1000 genomes];0.98[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs11186367	1.00[CEU][hapmap];1.00[CHB][hapmap];1.00[CHD][hapmap];1.00[GIH][hapmap];1.00[JPT][hapmap];1.00[MEX][hapmap];1.00[TSI][hapmap];0.96[AMR][1000 genomes];0.98[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs11186368	0.94[ASN][1000 genomes]
rs11498506	0.92[CHB][hapmap];0.83[JPT][hapmap];0.90[ASN][1000 genomes]
rs11498507	0.90[ASN][1000 genomes]
rs11498662	0.90[ASN][1000 genomes]
rs11527868	0.92[CHB][hapmap];0.96[CHD][hapmap];0.82[JPT][hapmap];0.90[ASN][1000 genomes]
rs12220866	0.92[CHB][hapmap];0.84[JPT][hapmap];0.86[ASN][1000 genomes]
rs12244538	0.91[ASN][1000 genomes]
rs12249377	0.92[CHB][hapmap];0.96[CHD][hapmap];0.84[JPT][hapmap];0.92[ASN][1000 genomes]
rs12255018	1.00[CEU][hapmap];1.00[CHB][hapmap];1.00[JPT][hapmap];0.83[YRI][hapmap];0.83[AFR][1000 genomes];0.95[AMR][1000 genomes];1.00[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs12256605	0.97[ASN][1000 genomes]
rs12258938	0.94[ASN][1000 genomes]
rs12261011	0.92[CHB][hapmap];0.96[CHD][hapmap];0.84[JPT][hapmap];0.90[ASN][1000 genomes]
rs12264160	0.92[CHB][hapmap];0.96[CHD][hapmap];0.92[JPT][hapmap];0.93[ASN][1000 genomes]
rs1573253	0.84[ASN][1000 genomes]
rs1592143	0.90[ASN][1000 genomes]
rs17102362	0.96[AMR][1000 genomes];0.97[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs1891311	1.00[CHB][hapmap];1.00[CHD][hapmap];1.00[JPT][hapmap];0.97[ASN][1000 genomes]
rs1891312	0.85[AFR][1000 genomes];0.95[AMR][1000 genomes];0.97[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs2901026	0.97[ASN][1000 genomes]
rs2901127	0.92[CHB][hapmap];0.96[CHD][hapmap];0.84[JPT][hapmap];0.92[ASN][1000 genomes]
rs3824739	0.85[CHD][hapmap]
rs4144422	0.94[ASW][hapmap];1.00[CEU][hapmap];1.00[CHB][hapmap];1.00[CHD][hapmap];1.00[GIH][hapmap];1.00[JPT][hapmap];1.00[LWK][hapmap];1.00[MEX][hapmap];1.00[MKK][hapmap];1.00[TSI][hapmap];1.00[YRI][hapmap];0.93[AFR][1000 genomes];0.96[AMR][1000 genomes];0.98[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs4282910	0.89[CEU][hapmap];1.00[CHB][hapmap];0.96[CHD][hapmap];1.00[JPT][hapmap];0.97[ASN][1000 genomes]
rs4284320	0.84[ASN][1000 genomes]
rs58578719	0.92[ASN][1000 genomes]
rs59257274	0.81[ASN][1000 genomes]
rs61481895	0.83[AFR][1000 genomes];0.95[AMR][1000 genomes];1.00[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs7082814	0.93[ASN][1000 genomes]
rs7085559	0.97[ASN][1000 genomes]
rs7096568	1.00[CEU][hapmap];1.00[CHB][hapmap];1.00[JPT][hapmap];0.96[YRI][hapmap];0.98[AFR][1000 genomes];0.96[AMR][1000 genomes];0.98[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs73315609	0.90[ASN][1000 genomes]
rs73315628	0.94[ASN][1000 genomes]
rs74148885	0.94[ASN][1000 genomes]
rs7478556	0.81[ASN][1000 genomes]
rs7903584	0.96[AMR][1000 genomes];0.98[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs7916720	1.00[CEU][hapmap];1.00[CHB][hapmap];1.00[JPT][hapmap];1.00[YRI][hapmap]

Variant overlapped rSNPs/rCNVs (count:1 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv831945	chr10:92590576-92793582	Active TSS Enhancers Flanking Active TSS Weak transcription Genic enhancers Flanking Bivalent TSS/Enh Strong transcription Transcr. at gene 5' and 3' Bivalent Enhancer Bivalent/Poised TSS ZNF genes & repeats	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	15 gene(s)	inside rSNPs	diseases

Variant related diseases (count:1)

Disease	PMID	Source
Economic and political preferences (time)	22566634	GWAS catalog

mRNA abundance (count:1)

SNP	Gene	Cis/trans	Tissue	Source
rs4586057	IFIT1	cis	parietal	SCAN

Chromatin state (count:125 , 50 per page) page: 1 2 3

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr10:92630400-92633000	Active TSS	NHDF-Ad	bronchial
2	chr10:92630600-92633200	Active TSS	iPS-20b Cell Line	embryonic stem cell
3	chr10:92630600-92633400	Active TSS	A549	lung
4	chr10:92630800-92633000	Active TSS	ES-WA7 Cell Line	embryonic stem cell
5	chr10:92630800-92633000	Flanking Active TSS	Primary hematopoietic stem cells G-CSF-mobilized Male	--
6	chr10:92631000-92633000	Active TSS	hESC Derived CD56+ Ectoderm Cultured Cells	ES cell derived
7	chr10:92631000-92633000	Active TSS	HUES64 Cell Line	embryonic stem cell
8	chr10:92631000-92633000	Active TSS	iPS-15b Cell Line	embryonic stem cell
9	chr10:92631000-92633000	Flanking Active TSS	Primary hematopoietic stem cells	blood
10	chr10:92631200-92633000	Active TSS	iPS-18 Cell Line	embryonic stem cell
11	chr10:92631200-92633400	Active TSS	HUES48 Cell Line	embryonic stem cell
12	chr10:92631200-92634000	Active TSS	GM12878-XiMat	blood
13	chr10:92632000-92633000	Flanking Active TSS	Primary hematopoietic stem cells G-CSF-mobilized Female	--
14	chr10:92632000-92633000	Flanking Active TSS	Cortex derived primary cultured neurospheres	brain
15	chr10:92632000-92633000	Flanking Active TSS	Skeletal Muscle Male	skeletal muscle
16	chr10:92632000-92633000	Flanking Active TSS	Monocytes-CD14+_RO01746	blood
17	chr10:92632200-92633000	Flanking Active TSS	Primary T helper naive cells fromperipheralblood	blood
18	chr10:92632200-92633000	Flanking Active TSS	Mesenchymal Stem Cell Derived Chondrocyte Cultured Cells	embryonic stem cell
19	chr10:92632200-92633000	Flanking Active TSS	Muscle Satellite Cultured Cells	--
20	chr10:92632200-92633000	Flanking Active TSS	Duodenum Mucosa	Duodenum
21	chr10:92632200-92633000	Flanking Active TSS	Duodenum Smooth Muscle	Duodenum
22	chr10:92632200-92633000	Flanking Active TSS	Skeletal Muscle Female	skeletal muscle
23	chr10:92632200-92633000	Flanking Active TSS	Stomach Smooth Muscle	stomach
24	chr10:92632200-92633000	Flanking Active TSS	HUVEC	blood vessel
25	chr10:92632200-92633000	Flanking Active TSS	NH-A	brain
26	chr10:92632200-92633000	Flanking Active TSS	NHLF	lung
27	chr10:92632200-92633600	Flanking Active TSS	Dnd41	blood
28	chr10:92632400-92633000	Flanking Active TSS	Mesenchymal Stem Cell Derived Adipocyte Cultured Cells	ES cell derived
29	chr10:92632400-92633000	Flanking Active TSS	Bone Marrow Derived Cultured Mesenchymal Stem Cells	Bone marrow
30	chr10:92632400-92633000	Flanking Active TSS	Ganglion Eminence derived primary cultured neurospheres	brain
31	chr10:92632400-92633000	Flanking Active TSS	Foreskin Keratinocyte Primary Cells skin02	Skin
32	chr10:92632400-92633000	Flanking Active TSS	Pancreatic Islets	Pancreatic Islet
33	chr10:92632400-92633000	Flanking Active TSS	Fetal Lung	lung
34	chr10:92632400-92633000	Flanking Active TSS	Rectal Mucosa Donor 29	rectum
35	chr10:92632400-92633000	Flanking Active TSS	Hela-S3	cervix
36	chr10:92632400-92633200	Flanking Active TSS	HMEC	breast
37	chr10:92632400-92633200	Flanking Active TSS	NHEK	skin
38	chr10:92632400-92633400	Flanking Active TSS	H9 Derived Neuron Cultured Cells	ES cell derived
39	chr10:92632400-92633600	Flanking Active TSS	H9 Derived Neuronal Progenitor Cultured Cells	ES cell derived
40	chr10:92632400-92633600	Enhancers	Primary monocytes fromperipheralblood	blood
41	chr10:92632400-92633800	Enhancers	Stomach Mucosa	stomach
42	chr10:92632400-92634800	Weak transcription	Primary Natural Killer cells fromperipheralblood	blood
43	chr10:92632400-92647800	Weak transcription	Aorta	Aorta
44	chr10:92632600-92633000	Flanking Active TSS	ES-I3 Cell Line	embryonic stem cell
45	chr10:92632600-92633000	Flanking Active TSS	hESC Derived CD56+ Mesoderm Cultured Cells	ES cell derived
46	chr10:92632600-92633000	Flanking Active TSS	HUES6 Cell Line	embryonic stem cell
47	chr10:92632600-92633000	Flanking Active TSS	Adipose Derived Mesenchymal Stem Cell Cultured Cells	ES cell derived
48	chr10:92632600-92633000	Flanking Active TSS	Breast variant Human Mammary Epithelial Cells (vHMEC)	Breast
49	chr10:92632600-92633000	Flanking Active TSS	Foreskin Fibroblast Primary Cells skin01	Skin
50	chr10:92632600-92633000	Flanking Active TSS	Brain Germinal Matrix	brain

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