Variant report

Variant	rs6690754
Chromosome Location	chr1:174847445-174847446
allele	A/G
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

TF binding
region (count:0)
CpG islands
(count:0)
Chromatin interactive
region (count:8)
LncRNA
region (count:0)
Mature miRNA
region (count: 0)
miRNA target
sites (count:0)

No data

(count:8 , 50 per page) page: 1

No.	Distal block	Cell Line	Cell type
1	chr1:174843626..174846037-chr1:174846205..174848852,2	K562	blood:
2	chr1:174846552..174849289-chr1:174966305..174968766,3	K562	blood:
3	chr1:174845505..174847927-chr1:174983132..174985506,2	K562	blood:
4	chr1:174846695..174849557-chr1:174878847..174881198,2	K562	blood:
5	chr1:174847246..174850144-chr1:174967841..174969392,2	MCF-7	breast:
6	chr1:174845164..174847813-chr1:174859843..174861856,2	K562	blood:
7	chr1:174838711..174843709-chr1:174844718..174847483,6	K562	blood:
8	chr1:174846515..174850739-chr1:174966957..174968897,3	MCF-7	breast:

No data

Variant related genes	Relation type
ENSG00000152061	Chromatin interaction
ENSG00000237249	Chromatin interaction
ENSG00000116161	Chromatin interaction
ENSG00000120333	Chromatin interaction

Extended variants
information (count: 191 )
Associated
traits (count: 2 )

rSNPs within LD-proxies of this variant (count:190)

rs_ID	r²[population]
rs1012182	0.87[AMR][1000 genomes];0.94[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs1034462	0.81[ASN][1000 genomes]
rs10494492	0.85[EUR][1000 genomes]
rs1058741	0.81[ASN][1000 genomes]
rs10798324	0.89[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs10798327	0.94[AFR][1000 genomes];0.96[AMR][1000 genomes];0.97[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs10912828	0.81[EUR][1000 genomes]
rs10912829	0.81[EUR][1000 genomes]
rs10912843	0.90[AFR][1000 genomes];0.93[AMR][1000 genomes];0.97[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs10912853	0.90[AMR][1000 genomes];0.93[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs10912855	0.87[AMR][1000 genomes];0.94[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs11800350	0.98[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs11806066	0.89[ASN][1000 genomes]
rs11806996	0.81[EUR][1000 genomes]
rs11809803	0.96[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs11810508	0.96[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs12063093	0.90[AMR][1000 genomes];0.94[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs12065825	0.81[EUR][1000 genomes]
rs12078839	0.83[AFR][1000 genomes];0.93[AMR][1000 genomes];0.97[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs12094876	0.87[AMR][1000 genomes];0.94[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs1231826	0.96[AFR][1000 genomes];0.97[AMR][1000 genomes];0.99[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs1231827	0.96[AFR][1000 genomes];0.96[AMR][1000 genomes];0.99[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs1231829	0.92[AFR][1000 genomes];0.84[AMR][1000 genomes];0.83[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs1329281	0.87[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs149099	0.81[EUR][1000 genomes]
rs1540207	0.84[EUR][1000 genomes]
rs1613634	0.91[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs1618207	0.87[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs1618408	0.82[ASN][1000 genomes]
rs1622802	0.87[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs162815	0.82[ASN][1000 genomes]
rs1653630	0.92[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs1653634	0.90[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs16847335	0.86[EUR][1000 genomes]
rs16847337	0.86[EUR][1000 genomes]
rs16847624	0.83[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs17302033	0.94[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs17302367	0.81[ASN][1000 genomes]
rs1754350	0.90[AFR][1000 genomes];0.92[AMR][1000 genomes];0.88[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs1754352	0.94[AFR][1000 genomes];0.95[AMR][1000 genomes];0.97[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs1754353	0.87[AFR][1000 genomes];0.82[AMR][1000 genomes];0.94[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs1754354	0.89[AFR][1000 genomes];0.82[AMR][1000 genomes];0.94[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs1754360	0.82[ASN][1000 genomes]
rs17842156	0.86[EUR][1000 genomes]
rs17842157	0.86[EUR][1000 genomes]
rs1793292	0.90[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs1793294	0.90[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs1793295	0.88[EUR][1000 genomes]
rs1793298	0.91[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs1793305	0.96[AFR][1000 genomes];0.96[AMR][1000 genomes];0.97[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs1793307	0.82[ASN][1000 genomes]
rs1793310	0.82[ASN][1000 genomes]
rs1793313	0.84[AFR][1000 genomes];0.90[ASN][1000 genomes]
rs1793316	0.87[AFR][1000 genomes];0.83[AMR][1000 genomes];0.94[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs1793318	0.88[AFR][1000 genomes];0.82[AMR][1000 genomes];0.93[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs1793320	0.92[EUR][1000 genomes]
rs1813136	0.88[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs1883139	0.98[AFR][1000 genomes];0.97[AMR][1000 genomes];1.00[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs1894198	0.92[AFR][1000 genomes];0.83[AMR][1000 genomes];0.82[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs1894199	0.92[AFR][1000 genomes];0.83[AMR][1000 genomes];0.83[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs1894201	0.96[AFR][1000 genomes];0.96[AMR][1000 genomes];0.97[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs1894680	0.82[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs1923818	0.88[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs193082	0.86[EUR][1000 genomes]
rs2003378	0.91[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs2060158	0.84[EUR][1000 genomes]
rs2146564	0.86[EUR][1000 genomes]
rs2157567	0.81[ASN][1000 genomes]
rs2163628	0.90[EUR][1000 genomes]
rs2183202	0.92[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs2568096	0.86[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs2568098	0.87[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs2760057	0.86[EUR][1000 genomes]
rs2760058	0.81[EUR][1000 genomes]
rs2771401	0.85[EUR][1000 genomes]
rs2860725	0.94[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs2861005	0.86[EUR][1000 genomes]
rs2861006	0.86[EUR][1000 genomes]
rs2981892	0.92[AFR][1000 genomes];0.85[AMR][1000 genomes];0.84[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs2981893	0.96[AFR][1000 genomes];0.97[AMR][1000 genomes];1.00[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs2981896	0.96[AFR][1000 genomes];0.97[AMR][1000 genomes];0.99[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs2987872	0.96[AFR][1000 genomes];0.96[AMR][1000 genomes];0.97[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs2987873	0.96[AFR][1000 genomes];0.96[AMR][1000 genomes];0.97[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs2987875	0.96[AMR][1000 genomes];0.99[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs2987876	0.95[AFR][1000 genomes];0.97[AMR][1000 genomes];0.97[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs2987880	0.85[AFR][1000 genomes];0.96[AMR][1000 genomes];0.97[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs3117838	0.88[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs3117843	0.86[EUR][1000 genomes]
rs3118982	0.91[AFR][1000 genomes];0.96[AMR][1000 genomes];1.00[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs3118986	0.94[AFR][1000 genomes];0.96[AMR][1000 genomes];0.97[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs3118987	0.97[AMR][1000 genomes];0.97[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs3118990	0.88[AFR][1000 genomes];0.82[AMR][1000 genomes];0.92[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs332767	0.87[EUR][1000 genomes]
rs332768	0.87[EUR][1000 genomes]
rs332779	0.88[EUR][1000 genomes]
rs332781	0.87[EUR][1000 genomes]
rs332782	0.87[EUR][1000 genomes]
rs332786	0.88[EUR][1000 genomes]
rs332793	0.85[EUR][1000 genomes]
rs332797	0.84[EUR][1000 genomes]
rs332800	0.88[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs332801	0.88[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs332802	0.80[EUR][1000 genomes]
rs332806	0.81[EUR][1000 genomes]
rs333422	0.87[EUR][1000 genomes]
rs333432	0.88[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs333436	0.87[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs333438	0.87[EUR][1000 genomes]
rs333452	0.83[EUR][1000 genomes]
rs333454	0.83[EUR][1000 genomes]
rs36127331	0.85[EUR][1000 genomes]
rs3766697	0.81[ASN][1000 genomes]
rs3862941	0.85[EUR][1000 genomes]
rs392307	0.87[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs395109	0.81[EUR][1000 genomes]
rs398350	0.88[EUR][1000 genomes]
rs399530	0.87[EUR][1000 genomes]
rs411665	0.84[EUR][1000 genomes]
rs4480415	0.82[EUR][1000 genomes]
rs458242	0.88[EUR][1000 genomes]
rs459078	0.82[ASN][1000 genomes]
rs460878	0.87[EUR][1000 genomes]
rs464540	0.86[EUR][1000 genomes]
rs464635	0.87[EUR][1000 genomes];0.87[ASN][1000 genomes]
rs4651114	0.81[EUR][1000 genomes]
rs4651205	0.97[ASN][1000 genomes]
rs4651231	0.90[AMR][1000 genomes];0.91[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs4651235	0.87[AMR][1000 genomes];0.93[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs4652797	0.91[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs467437	0.88[EUR][1000 genomes]
rs55667039	0.85[EUR][1000 genomes]
rs55688014	0.86[EUR][1000 genomes]
rs55774740	0.81[ASN][1000 genomes]
rs55793234	0.92[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs55844798	0.86[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs57289077	0.97[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs58030712	0.87[AMR][1000 genomes];0.84[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs60482554	0.87[AMR][1000 genomes];0.84[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs60811893	0.86[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs6425298	0.95[AFR][1000 genomes];0.96[AMR][1000 genomes];1.00[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs6425300	0.88[AFR][1000 genomes];0.97[AMR][1000 genomes];0.99[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs6425301	0.94[AFR][1000 genomes];0.97[AMR][1000 genomes];0.99[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs6425304	0.88[AMR][1000 genomes];0.85[EUR][1000 genomes]
rs6425306	0.85[AMR][1000 genomes];0.92[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs6667107	0.81[EUR][1000 genomes]
rs6671196	0.92[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs6671272	0.88[AMR][1000 genomes];0.92[EUR][1000 genomes];0.87[ASN][1000 genomes]
rs6671782	0.90[AMR][1000 genomes];0.94[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs66836419	0.94[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs6684229	0.90[AMR][1000 genomes];0.94[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs6684515	0.90[AMR][1000 genomes];0.94[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs6686872	0.91[AFR][1000 genomes];0.97[AMR][1000 genomes];0.95[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs6687616	0.95[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs6689153	0.81[EUR][1000 genomes]
rs6693979	0.90[AFR][1000 genomes];0.97[AMR][1000 genomes];0.99[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs6696465	0.87[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs6700953	0.89[AFR][1000 genomes];0.85[AMR][1000 genomes];0.85[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs67054007	0.83[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs67133776	0.90[AMR][1000 genomes];0.92[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs67203477	0.94[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs67903803	0.94[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs72715273	0.81[EUR][1000 genomes]
rs72715281	0.86[EUR][1000 genomes]
rs72715292	0.85[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs72715294	0.83[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs72715300	0.86[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs72717608	0.87[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs72717616	0.92[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs72717617	0.90[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs72717618	0.93[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs72717630	0.94[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs72717637	0.82[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs72717649	0.94[EUR][1000 genomes];0.97[ASN][1000 genomes]
rs72717650	0.94[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs72717653	0.94[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs72717661	0.92[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs72717670	0.81[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs74128535	0.81[ASN][1000 genomes]
rs7516353	0.81[EUR][1000 genomes]
rs7516410	0.94[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs7521109	0.92[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs7531032	0.81[ASN][1000 genomes]
rs7543147	0.87[AMR][1000 genomes];0.94[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs7547658	0.98[AFR][1000 genomes];0.97[AMR][1000 genomes];1.00[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs7554767	0.81[ASN][1000 genomes]
rs913686	0.99[AFR][1000 genomes];0.97[AMR][1000 genomes];0.97[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs913687	0.82[ASN][1000 genomes]
rs913688	0.94[EUR][1000 genomes];0.84[ASN][1000 genomes]
rs9425787	0.98[AFR][1000 genomes];0.97[AMR][1000 genomes];1.00[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs989424	0.81[AMR][1000 genomes];0.94[EUR][1000 genomes];0.89[ASN][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:1 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	esv2755184	chr1:174388343-174970343	Flanking Active TSS Weak transcription Enhancers Strong transcription Transcr. at gene 5' and 3' Genic enhancers Active TSS ZNF genes & repeats Flanking Bivalent TSS/Enh Bivalent/Poised TSS Bivalent Enhancer	TF binding region CpG island Chromatin interactive region lncRNA	54 gene(s)	inside rSNPs	diseases

mRNA abundance (count:2)

SNP	Gene	Cis/trans	Tissue	Source
rs6690754	RABGAP1L	cis	Esophagus Muscularis	GTEx
rs6690754	MRPS14	Cis_1M	lymphoblastoid	RTeQTL

Chromatin state (count:52 , 50 per page) page: 1 2

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr1:174843400-174847600	Active TSS	Fetal Intestine Large	intestine
2	chr1:174844000-174852000	Weak transcription	Left Ventricle	heart
3	chr1:174844000-174855200	Weak transcription	Right Atrium	heart
4	chr1:174844200-174852400	Weak transcription	Adipose Nuclei	Adipose
5	chr1:174844600-174853000	Weak transcription	Primary hematopoietic stem cells	blood
6	chr1:174844800-174852600	Weak transcription	Primary B cells from peripheral blood	blood
7	chr1:174844800-174871600	Weak transcription	Breast variant Human Mammary Epithelial Cells (vHMEC)	Breast
8	chr1:174844800-174874400	Weak transcription	Primary mononuclear cells fromperipheralblood	Blood
9	chr1:174844800-174877400	Weak transcription	H1 Derived Mesenchymal Stem Cells	ES cell derived
10	chr1:174845000-174850200	Weak transcription	Fetal Kidney	kidney
11	chr1:174845000-174856200	Weak transcription	Primary B cells from cord blood	blood
12	chr1:174845000-174862800	Weak transcription	Primary T killer memory cells from peripheral blood	blood
13	chr1:174845000-174863000	Weak transcription	Primary T cells from cord blood	blood
14	chr1:174845200-174849400	Weak transcription	Primary monocytes fromperipheralblood	blood
15	chr1:174845200-174852600	Weak transcription	Monocytes-CD14+_RO01746	blood
16	chr1:174845200-174862600	Weak transcription	Liver	Liver
17	chr1:174846200-174861200	Weak transcription	GM12878-XiMat	blood
18	chr1:174846400-174847800	Active TSS	Pancreas	Pancrea
19	chr1:174846600-174862800	Weak transcription	Primary T helper naive cells from peripheral blood	blood
20	chr1:174846800-174847600	Strong transcription	H9 Cell Line	embryonic stem cell
21	chr1:174846800-174847600	Transcr. at gene 5' and 3'	iPS-15b Cell Line	embryonic stem cell
22	chr1:174846800-174847600	Strong transcription	iPS DF 6.9 Cell Line	embryonic stem cell
23	chr1:174846800-174847600	Active TSS	Fetal Intestine Small	intestine
24	chr1:174846800-174848400	Weak transcription	iPS DF 19.11 Cell Line	embryonic stem cell
25	chr1:174846800-174850600	Weak transcription	Cortex derived primary cultured neurospheres	brain
26	chr1:174846800-174852200	Weak transcription	hESC Derived CD56+ Ectoderm Cultured Cells	ES cell derived
27	chr1:174846800-174852400	Weak transcription	Brain Dorsolateral Prefrontal Cortex	brain
28	chr1:174846800-174852600	Weak transcription	Small Intestine	intestine
29	chr1:174846800-174855200	Weak transcription	Primary Natural Killer cells fromperipheralblood	blood
30	chr1:174846800-174855200	Weak transcription	Sigmoid Colon	Sigmoid Colon
31	chr1:174846800-174861000	Weak transcription	Primary T helper memory cells from peripheral blood 1	blood
32	chr1:174846800-174874000	Weak transcription	Ovary	ovary
33	chr1:174847000-174852400	Weak transcription	HSMMtube	muscle
34	chr1:174847000-174855400	Weak transcription	Colonic Mucosa	Colon
35	chr1:174847000-174869200	Weak transcription	ES-I3 Cell Line	embryonic stem cell
36	chr1:174847200-174847600	Genic enhancers	ES-UCSF4 Cell Line	embryonic stem cell
37	chr1:174847200-174847600	Flanking Active TSS	K562	blood
38	chr1:174847200-174852600	Weak transcription	Fetal Lung	lung
39	chr1:174847200-174853000	Weak transcription	Duodenum Smooth Muscle	Duodenum
40	chr1:174847400-174847600	Enhancers	Esophagus	oesophagus
41	chr1:174847400-174847600	Active TSS	Pancreatic Islets	Pancreatic Islet
42	chr1:174847400-174848600	Strong transcription	iPS-20b Cell Line	embryonic stem cell
43	chr1:174847400-174848600	Weak transcription	Stomach Mucosa	stomach
44	chr1:174847400-174849000	Strong transcription	iPS-18 Cell Line	embryonic stem cell
45	chr1:174847400-174849000	Weak transcription	Fetal Stomach	stomach
46	chr1:174847400-174849200	Strong transcription	HUES64 Cell Line	embryonic stem cell
47	chr1:174847400-174852000	Weak transcription	Duodenum Mucosa	Duodenum
48	chr1:174847400-174862800	Weak transcription	Rectal Mucosa Donor 31	rectum
49	chr1:174847400-174863000	Weak transcription	Rectal Mucosa Donor 29	rectum
50	chr1:174847400-174864400	Strong transcription	HUES6 Cell Line	embryonic stem cell

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