Variant report

Variant	rs74121889
Chromosome Location	chr10:22981342-22981343
allele	A/G
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Transcrition factor	Chromosome Location	Cell Line	Cell type	Cell Stage	Matched TF binding sites
1	POLR2A	chr10:22981101-22981914	GM12892	blood:	n/a	n/a

No.	Distal block	Cell Line	Cell type	Cell Stage
1	chr10:22903368..22907136-chr10:22980812..22983747,3	K562	blood:
2	chr10:22979232..22981528-chr10:23001469..23003745,3	MCF-7	breast:

Variant related genes	Relation type
PIP4K2A	TF binding region
ENSG00000150867	Chromatin interaction

Extended variants
information (count: 66 )
Associated
traits (count: 0)

rSNPs within LD-proxies of this variant (count:64)

rs_ID	r²[population]
rs11013124	0.83[EUR][1000 genomes]
rs12240894	0.83[EUR][1000 genomes]
rs12256270	0.83[EUR][1000 genomes]
rs12266336	0.83[EUR][1000 genomes]
rs12266776	0.83[EUR][1000 genomes]
rs12267858	0.83[EUR][1000 genomes]
rs1343505	0.93[ASN][1000 genomes]
rs1544228	0.89[ASN][1000 genomes]
rs16922558	0.88[ASN][1000 genomes]
rs16922574	0.88[ASN][1000 genomes]
rs16922601	0.95[AFR][1000 genomes];0.86[EUR][1000 genomes]
rs16922612	0.94[AFR][1000 genomes];0.83[AMR][1000 genomes]
rs16922619	1.00[ASN][1000 genomes]
rs16922627	0.86[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs16922629	0.83[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs16922631	0.86[EUR][1000 genomes];0.91[ASN][1000 genomes]
rs16922641	0.83[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs16922673	0.83[EUR][1000 genomes];0.93[ASN][1000 genomes]
rs16922697	0.83[EUR][1000 genomes]
rs2032025	0.86[EUR][1000 genomes]
rs2032026	1.00[EUR][1000 genomes]
rs2032027	1.00[EUR][1000 genomes]
rs2068726	0.89[ASN][1000 genomes]
rs2153534	0.84[ASN][1000 genomes]
rs55855627	0.83[EUR][1000 genomes];0.93[ASN][1000 genomes]
rs56412842	0.88[ASN][1000 genomes]
rs57280862	0.86[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs58587913	0.83[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs58847346	0.95[ASN][1000 genomes]
rs59134467	0.83[EUR][1000 genomes];0.93[ASN][1000 genomes]
rs59278361	0.83[EUR][1000 genomes];0.93[ASN][1000 genomes]
rs59573145	0.89[ASN][1000 genomes]
rs59760845	0.83[EUR][1000 genomes]
rs59908513	0.86[EUR][1000 genomes];0.95[ASN][1000 genomes]
rs60284138	0.88[ASN][1000 genomes]
rs61295423	0.83[EUR][1000 genomes];0.93[ASN][1000 genomes]
rs61587496	0.83[EUR][1000 genomes];0.93[ASN][1000 genomes]
rs6482231	0.95[ASN][1000 genomes]
rs6482237	0.89[ASN][1000 genomes]
rs67864649	0.93[ASN][1000 genomes]
rs7070712	0.91[ASN][1000 genomes]
rs7078244	0.93[ASN][1000 genomes]
rs7078735	0.94[AFR][1000 genomes];0.83[AMR][1000 genomes];0.86[EUR][1000 genomes]
rs72816902	0.93[ASN][1000 genomes]
rs73598599	0.86[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs73598600	0.86[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs73598601	0.86[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs73600503	0.86[EUR][1000 genomes];0.91[ASN][1000 genomes]
rs74121608	0.83[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs74121610	0.83[EUR][1000 genomes]
rs74121611	0.83[EUR][1000 genomes]
rs74121869	0.92[AFR][1000 genomes];1.00[EUR][1000 genomes]
rs74121888	0.95[AFR][1000 genomes];0.86[EUR][1000 genomes]
rs74121890	0.91[AFR][1000 genomes];0.83[AMR][1000 genomes];0.86[EUR][1000 genomes]
rs74121891	0.83[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs74121893	0.83[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs74121894	0.83[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs74121897	0.83[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs74125205	0.83[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs74125206	0.83[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs7906229	0.89[ASN][1000 genomes]
rs7914338	0.86[ASN][1000 genomes]
rs7917205	0.89[ASN][1000 genomes]
rs9651372	0.83[EUR][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:2 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	esv1830947	chr10:22881196-23004381	Weak transcription Flanking Active TSS Enhancers Genic enhancers Strong transcription Active TSS Bivalent/Poised TSS ZNF genes & repeats Transcr. at gene 5' and 3' Flanking Bivalent TSS/Enh Bivalent Enhancer	TF binding region CpG island Chromatin interactive region lncRNA	8 gene(s)	inside rSNPs	diseases
2	nsv831809	chr10:22918101-23069676	Weak transcription Enhancers Flanking Active TSS Genic enhancers Transcr. at gene 5' and 3' Active TSS Strong transcription Bivalent Enhancer Flanking Bivalent TSS/Enh ZNF genes & repeats Bivalent/Poised TSS	TF binding region CpG island Chromatin interactive region lncRNA	7 gene(s)	inside rSNPs	diseases

No data

Chromatin state (count:80 , 50 per page) page: 1 2

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr10:22970600-22989000	Weak transcription	Esophagus	oesophagus
2	chr10:22972600-22983600	Enhancers	Brain Substantia Nigra	brain
3	chr10:22972600-23000200	Enhancers	Primary T killer naive cells fromperipheralblood	blood
4	chr10:22972800-22990000	Weak transcription	Rectal Mucosa Donor 29	rectum
5	chr10:22972800-22999400	Enhancers	Primary T helper cells fromperipheralblood	blood
6	chr10:22973000-22988200	Weak transcription	Aorta	Aorta
7	chr10:22973000-22990000	Enhancers	Primary T helper 17 cells PMA-I stimulated	--
8	chr10:22973000-22997600	Enhancers	Primary T helper memory cells from peripheral blood 2	blood
9	chr10:22973000-22999200	Enhancers	Primary T helper naive cells from peripheral blood	blood
10	chr10:22973200-22981600	Enhancers	Primary T cells effector/memory enriched fromperipheralblood	blood
11	chr10:22973200-22987400	Enhancers	Primary T helper naive cells fromperipheralblood	blood
12	chr10:22973200-22989400	Enhancers	Primary T killer memory cells from peripheral blood	blood
13	chr10:22973800-22985800	Weak transcription	Fetal Heart	heart
14	chr10:22974000-22985400	Weak transcription	Colon Smooth Muscle	Colon
15	chr10:22974600-22982600	Weak transcription	Duodenum Smooth Muscle	Duodenum
16	chr10:22974800-22988200	Weak transcription	Duodenum Mucosa	Duodenum
17	chr10:22974800-22988400	Weak transcription	Rectal Mucosa Donor 31	rectum
18	chr10:22975000-22982600	Weak transcription	Gastric	stomach
19	chr10:22975600-23001200	Weak transcription	Colonic Mucosa	Colon
20	chr10:22976000-22984000	Enhancers	Primary T regulatory cells fromperipheralblood	blood
21	chr10:22976000-22984400	Weak transcription	Foreskin Melanocyte Primary Cells skin01	Skin
22	chr10:22976000-22989000	Weak transcription	Thymus	Thymus
23	chr10:22977200-22998400	Enhancers	Primary T helper memory cells from peripheral blood 1	blood
24	chr10:22977600-22999200	Weak transcription	Dnd41	blood
25	chr10:22978200-22988200	Weak transcription	Left Ventricle	heart
26	chr10:22978600-22983000	Enhancers	Fetal Adrenal Gland	Adrenal Gland
27	chr10:22978600-22983400	Enhancers	Primary monocytes fromperipheralblood	blood
28	chr10:22978800-22981600	Enhancers	Primary T cells from cord blood	blood
29	chr10:22978800-22982400	Weak transcription	Primary mononuclear cells fromperipheralblood	Blood
30	chr10:22979400-22983400	Enhancers	Brain Angular Gyrus	brain
31	chr10:22979400-22984800	Enhancers	Brain Hippocampus Middle	brain
32	chr10:22979800-22983200	Enhancers	Primary Natural Killer cells fromperipheralblood	blood
33	chr10:22979800-22983400	Enhancers	Primary T cells fromperipheralblood	blood
34	chr10:22979800-22983600	Enhancers	Primary B cells from peripheral blood	blood
35	chr10:22980200-22981600	Weak transcription	Brain Anterior Caudate	brain
36	chr10:22980200-22981800	Weak transcription	Adipose Derived Mesenchymal Stem Cell Cultured Cells	ES cell derived
37	chr10:22980200-22981800	Weak transcription	NHLF	lung
38	chr10:22980200-22982000	Weak transcription	Mesenchymal Stem Cell Derived Chondrocyte Cultured Cells	embryonic stem cell
39	chr10:22980200-22982200	Weak transcription	Osteobl	bone
40	chr10:22980200-22982400	Weak transcription	IMR90 fetal lung fibroblasts Cell Line	lung
41	chr10:22980200-22982400	Weak transcription	Bone Marrow Derived Cultured Mesenchymal Stem Cells	Bone marrow
42	chr10:22980200-22982600	Weak transcription	H1 Derived Mesenchymal Stem Cells	ES cell derived
43	chr10:22980200-22983000	Weak transcription	Brain Inferior Temporal Lobe	brain
44	chr10:22980200-22983400	Enhancers	Monocytes-CD14+_RO01746	blood
45	chr10:22980200-22986800	Weak transcription	Adipose Nuclei	Adipose
46	chr10:22980200-22987800	Weak transcription	Fetal Lung	lung
47	chr10:22980200-22988200	Weak transcription	Pancreas	Pancrea
48	chr10:22980200-22988200	Weak transcription	Spleen	Spleen
49	chr10:22980200-22993600	Weak transcription	H1 BMP4 Derived Trophoblast Cultured Cells	ES cell derived
50	chr10:22980400-22981400	Weak transcription	Liver	Liver

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