Variant report

Variant	rs11623457
Chromosome Location	chr14:64958106-64958107
allele	A/C
Outlinks	Ensembl UCSC

Chromatin state
Related regulatory elements
Target genes
Other information

No.	Distal block	Cell Line	Cell type	Cell Stage
1	chr14:64957408..64961833-chr14:64968982..64972745,8	MCF-7	breast:

Variant related genes	Relation type
ENSG00000126804	Chromatin interaction
ENSG00000089775	Chromatin interaction

Extended variants
information (count: 96 )
Associated
traits (count: 5 )

rSNPs within LD-proxies of this variant (count:95)

rs_ID	r²[population]
rs10131155	0.90[ASN][1000 genomes]
rs10131416	0.95[AMR][1000 genomes];1.00[EUR][1000 genomes]
rs10132424	0.86[ASN][1000 genomes]
rs10132969	1.00[AFR][1000 genomes];0.95[AMR][1000 genomes];1.00[EUR][1000 genomes]
rs10133243	0.89[ASN][1000 genomes]
rs10133411	0.88[ASN][1000 genomes]
rs10133696	0.87[AFR][1000 genomes];0.98[AMR][1000 genomes];0.99[EUR][1000 genomes];0.89[ASN][1000 genomes]
rs10133848	0.95[AMR][1000 genomes];0.99[EUR][1000 genomes]
rs10134530	1.00[AFR][1000 genomes];0.95[AMR][1000 genomes];1.00[EUR][1000 genomes]
rs10136732	0.96[AFR][1000 genomes];0.95[AMR][1000 genomes];1.00[EUR][1000 genomes]
rs10138256	0.88[ASN][1000 genomes]
rs10142835	0.88[ASN][1000 genomes]
rs10142879	1.00[AFR][1000 genomes];1.00[AMR][1000 genomes];0.99[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs10143170	0.88[ASN][1000 genomes]
rs10143839	1.00[AFR][1000 genomes];0.95[AMR][1000 genomes];1.00[EUR][1000 genomes]
rs10145001	0.85[AMR][1000 genomes];0.90[EUR][1000 genomes]
rs10145005	0.89[AMR][1000 genomes];1.00[EUR][1000 genomes]
rs10145013	1.00[AFR][1000 genomes];0.92[AMR][1000 genomes];0.99[EUR][1000 genomes]
rs10147522	0.84[AMR][1000 genomes];0.91[EUR][1000 genomes]
rs10149286	0.88[ASN][1000 genomes]
rs10150781	1.00[AFR][1000 genomes];0.95[AMR][1000 genomes];1.00[EUR][1000 genomes]
rs10873173	1.00[AFR][1000 genomes];1.00[AMR][1000 genomes];0.99[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs11158542	0.90[EUR][1000 genomes]
rs11158543	0.92[AFR][1000 genomes];0.98[AMR][1000 genomes];0.98[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs11158544	0.88[ASN][1000 genomes]
rs11625265	0.95[AMR][1000 genomes];0.94[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs11626222	1.00[AFR][1000 genomes];0.95[AMR][1000 genomes];0.99[EUR][1000 genomes]
rs11627387	0.84[AMR][1000 genomes];0.95[EUR][1000 genomes]
rs11628221	1.00[AFR][1000 genomes];1.00[AMR][1000 genomes];0.99[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs11845653	0.89[AFR][1000 genomes];0.95[AMR][1000 genomes];1.00[EUR][1000 genomes]
rs11847054	0.88[ASN][1000 genomes]
rs11848179	0.97[AMR][1000 genomes];0.99[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs11849935	1.00[AFR][1000 genomes];0.95[AMR][1000 genomes];1.00[EUR][1000 genomes]
rs11851236	0.84[AMR][1000 genomes];0.91[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs12050238	1.00[AFR][1000 genomes];1.00[AMR][1000 genomes];0.99[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs12050358	1.00[AFR][1000 genomes];1.00[AMR][1000 genomes];0.99[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs12385910	0.87[ASN][1000 genomes]
rs12385918	0.88[ASN][1000 genomes]
rs12586212	0.90[ASN][1000 genomes]
rs12588886	0.88[ASN][1000 genomes]
rs12589947	0.89[ASN][1000 genomes]
rs1453004	0.88[ASN][1000 genomes]
rs1453007	0.97[AMR][1000 genomes];0.99[EUR][1000 genomes];0.96[ASN][1000 genomes]
rs1453009	0.88[ASN][1000 genomes]
rs1470851	0.93[AMR][1000 genomes];0.98[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs17101896	0.88[ASN][1000 genomes]
rs1966865	0.97[AMR][1000 genomes];0.99[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs1980519	1.00[AFR][1000 genomes];1.00[AMR][1000 genomes];0.99[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs1980520	1.00[AFR][1000 genomes];1.00[AMR][1000 genomes];0.99[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs1982440	0.83[AFR][1000 genomes];0.90[ASN][1000 genomes]
rs2045024	0.95[AMR][1000 genomes];0.99[EUR][1000 genomes]
rs2123459	1.00[AFR][1000 genomes];0.94[AMR][1000 genomes];1.00[EUR][1000 genomes]
rs2123460	1.00[AFR][1000 genomes];0.92[AMR][1000 genomes];0.98[EUR][1000 genomes]
rs2198347	0.87[AFR][1000 genomes];1.00[AMR][1000 genomes];0.99[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs28446048	0.90[ASN][1000 genomes]
rs28469649	1.00[AMR][1000 genomes];0.99[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs28626711	0.88[ASN][1000 genomes]
rs28666045	1.00[AFR][1000 genomes];0.97[AMR][1000 genomes];0.97[EUR][1000 genomes];0.94[ASN][1000 genomes]
rs28730549	0.88[AMR][1000 genomes];0.91[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs28738919	1.00[AFR][1000 genomes];1.00[AMR][1000 genomes];1.00[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs28766386	0.95[AMR][1000 genomes];1.00[EUR][1000 genomes]
rs28827477	0.92[AMR][1000 genomes];0.93[EUR][1000 genomes]
rs35115595	1.00[AFR][1000 genomes];0.95[AMR][1000 genomes];0.99[EUR][1000 genomes]
rs35451957	0.88[ASN][1000 genomes]
rs3742606	0.95[AMR][1000 genomes];1.00[EUR][1000 genomes]
rs3742608	0.95[AMR][1000 genomes];0.98[EUR][1000 genomes]
rs3783722	0.88[ASN][1000 genomes]
rs3783723	0.90[ASN][1000 genomes]
rs3783724	0.90[ASN][1000 genomes]
rs3783727	0.84[EUR][1000 genomes]
rs4632045	1.00[AFR][1000 genomes];1.00[AMR][1000 genomes];1.00[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs57525201	1.00[AFR][1000 genomes];0.95[AMR][1000 genomes];1.00[EUR][1000 genomes]
rs58893738	0.88[ASN][1000 genomes]
rs59213791	0.83[AFR][1000 genomes];0.91[ASN][1000 genomes]
rs59440409	0.89[ASN][1000 genomes]
rs59512674	0.88[ASN][1000 genomes]
rs59577187	1.00[AFR][1000 genomes];0.95[AMR][1000 genomes];1.00[EUR][1000 genomes]
rs60908674	0.89[ASN][1000 genomes]
rs61615397	0.89[ASN][1000 genomes]
rs61985663	1.00[AFR][1000 genomes];0.95[AMR][1000 genomes];0.99[EUR][1000 genomes]
rs61985668	0.98[AMR][1000 genomes];1.00[EUR][1000 genomes];1.00[ASN][1000 genomes]
rs61985706	0.97[AMR][1000 genomes];0.98[EUR][1000 genomes];0.98[ASN][1000 genomes]
rs61985707	0.90[ASN][1000 genomes]
rs61985711	0.88[ASN][1000 genomes]
rs6573559	0.89[AMR][1000 genomes];0.96[EUR][1000 genomes]
rs7160634	0.86[AMR][1000 genomes];0.85[EUR][1000 genomes];0.88[ASN][1000 genomes]
rs73265639	1.00[AFR][1000 genomes];0.95[AMR][1000 genomes];1.00[EUR][1000 genomes]
rs73265640	0.89[AFR][1000 genomes];0.95[AMR][1000 genomes];1.00[EUR][1000 genomes]
rs73265641	1.00[AFR][1000 genomes];0.95[AMR][1000 genomes];0.99[EUR][1000 genomes]
rs73267743	0.90[ASN][1000 genomes]
rs73267744	0.90[ASN][1000 genomes]
rs745686	0.85[EUR][1000 genomes]
rs926803	0.86[AMR][1000 genomes];0.90[EUR][1000 genomes];0.90[ASN][1000 genomes]
rs9323451	0.98[AMR][1000 genomes];0.96[EUR][1000 genomes]
rs9323452	1.00[AMR][1000 genomes];0.99[EUR][1000 genomes];0.98[ASN][1000 genomes]

Variant overlapped rSNPs/rCNVs (count:1 , 50 per page) page: 1

No.	Variant name	Chromosome position	Chromatin state	Related regulatory elements	Target genes	Extended variants	Associated traits
1	nsv902022	chr14:64926581-64958638	Weak transcription Genic enhancers Active TSS Flanking Active TSS Enhancers Strong transcription Bivalent Enhancer Bivalent/Poised TSS Flanking Bivalent TSS/Enh Transcr. at gene 5' and 3'	TF binding region CpG island Chromatin interactive region lncRNA miRNA target site	7 gene(s)	inside rSNPs	diseases

mRNA abundance (count:5)

SNP	Gene	Cis/trans	Tissue	Source
rs11623457	ZBTB25	cis	lung	GTEx
rs11623457	ZBTB1	Cis_1M	lymphoblastoid	RTeQTL
rs11623457	ZBTB25	cis	multi-tissue	Pritchard
rs11623457	ZBTB25	cis	Nerve Tibial	GTEx
rs11623457	ZBTB25	Cis_1M	lymphoblastoid	RTeQTL

Chromatin state (count:124 , 50 per page) page: 1 2 3

No.	Chromosome Location	Chromatin state	Cell line	Tissue
1	chr14:64933200-64968400	Weak transcription	Foreskin Melanocyte Primary Cells skin01	Skin
2	chr14:64933400-64968200	Weak transcription	ES-I3 Cell Line	embryonic stem cell
3	chr14:64936800-64968400	Weak transcription	Fetal Brain Male	brain
4	chr14:64945000-64958200	Strong transcription	Primary T regulatory cells fromperipheralblood	blood
5	chr14:64949000-64958400	Weak transcription	iPS DF 19.11 Cell Line	embryonic stem cell
6	chr14:64949600-64958800	Weak transcription	iPS DF 6.9 Cell Line	embryonic stem cell
7	chr14:64950000-64968200	Weak transcription	Colonic Mucosa	Colon
8	chr14:64950400-64958800	Strong transcription	Dnd41	blood
9	chr14:64950400-64963000	Strong transcription	Fetal Thymus	thymus
10	chr14:64950600-64967800	Weak transcription	HUVEC	blood vessel
11	chr14:64950800-64958400	Strong transcription	Mesenchymal Stem Cell Derived Chondrocyte Cultured Cells	embryonic stem cell
12	chr14:64951000-64958600	Strong transcription	H9 Derived Neuronal Progenitor Cultured Cells	ES cell derived
13	chr14:64951000-64958600	Strong transcription	hESC Derived CD56+ Mesoderm Cultured Cells	ES cell derived
14	chr14:64951600-64958600	Strong transcription	Breast variant Human Mammary Epithelial Cells (vHMEC)	Breast
15	chr14:64951600-64958600	Strong transcription	Monocytes-CD14+_RO01746	blood
16	chr14:64951800-64958400	Strong transcription	Primary hematopoietic stem cells G-CSF-mobilized Female	--
17	chr14:64951800-64958800	Strong transcription	Fetal Muscle Trunk	muscle
18	chr14:64952200-64968000	Weak transcription	H1 BMP4 Derived Mesendoderm Cultured Cells	ES cell derived
19	chr14:64952600-64958600	Strong transcription	HUES48 Cell Line	embryonic stem cell
20	chr14:64953000-64960200	Weak transcription	K562	blood
21	chr14:64953200-64958400	Strong transcription	HUES64 Cell Line	embryonic stem cell
22	chr14:64953200-64968200	Weak transcription	Placenta Amnion	Placenta Amnion
23	chr14:64953600-64958600	Strong transcription	Primary B cells from cord blood	blood
24	chr14:64953600-64958600	Strong transcription	Foreskin Keratinocyte Primary Cells skin02	Skin
25	chr14:64953600-64958800	Strong transcription	HUES6 Cell Line	embryonic stem cell
26	chr14:64953600-64959200	Strong transcription	Fetal Stomach	stomach
27	chr14:64953600-64959600	Strong transcription	Primary T cells from cord blood	blood
28	chr14:64953600-64959800	Strong transcription	GM12878-XiMat	blood
29	chr14:64954000-64959200	Strong transcription	Fetal Intestine Small	intestine
30	chr14:64954600-64958200	Weak transcription	Psoas Muscle	Psoas
31	chr14:64954600-64962000	Weak transcription	Foreskin Fibroblast Primary Cells skin01	Skin
32	chr14:64954600-64966600	Weak transcription	HepG2	liver
33	chr14:64954600-64968000	Weak transcription	Rectal Smooth Muscle	rectum
34	chr14:64954600-64968200	Weak transcription	Foreskin Fibroblast Primary Cells skin02	Skin
35	chr14:64954600-64968400	Weak transcription	Esophagus	oesophagus
36	chr14:64954600-64968400	Weak transcription	Gastric	stomach
37	chr14:64954600-64968400	Weak transcription	Pancreas	Pancrea
38	chr14:64954800-64960600	Weak transcription	Ovary	ovary
39	chr14:64954800-64962000	Weak transcription	Aorta	Aorta
40	chr14:64954800-64966200	Weak transcription	Small Intestine	intestine
41	chr14:64954800-64966400	Weak transcription	Muscle Satellite Cultured Cells	--
42	chr14:64954800-64966400	Weak transcription	Pancreatic Islets	Pancreatic Islet
43	chr14:64954800-64968200	Weak transcription	IMR90 fetal lung fibroblasts Cell Line	lung
44	chr14:64954800-64968200	Weak transcription	HSMMtube	muscle
45	chr14:64954800-64968400	Weak transcription	H1 Cell Line	embryonic stem cell
46	chr14:64954800-64968400	Weak transcription	H9 Cell Line	embryonic stem cell
47	chr14:64954800-64968400	Weak transcription	Sigmoid Colon	Sigmoid Colon
48	chr14:64954800-64968400	Weak transcription	Spleen	Spleen
49	chr14:64954800-64969600	Weak transcription	H1 Derived Neuronal Progenitor Cultured Cells	ES cell derived
50	chr14:64955000-64961800	Weak transcription	Brain Angular Gyrus	brain

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